The effectiveness of high energy neon ions in producing chromosomal aberrations in human lymphocytes

Alan Edwards*, Paul Finnon, Jayne Moquet, D. C. Lloyd, F. Darroudi, A. T. Natarajan

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

20 Citations (Scopus)

Abstract

This paper presents the results of the observation of chromosomal aberrations in human lymphocytes following irradiation by 189 MeV 20Ne ions. Dicentrics were observed at the first metaphase and chromosomal breaks at early interphase using the premature chromosome condensation technique (PCC). Comparison of these measurements with previous work with low LET radiation, produced RBE(m) values of 0.3 and 0.6 for dicentrics at metaphase and for breaks in early interphase, respectively. Recently published work on the repair of double strand breaks using the PCC technique shows that following X irradiation, the dicentric yield does not alter with repair time but the breaks decrease with repair time with a time constant in the region of 1 or 2 h. More recently published data in which cultures of mixed irradiated and unirradiated cells were scored for both dicentrics at metaphase and breaks at early interphase show that interphase death affects the dicentric yield at metaphase but not the break yield at early interphase. These observations place restrictions on the acceptability of models of radiation action.

Original languageEnglish
Pages (from-to)299-303
Number of pages5
JournalRadiation Protection Dosimetry
Volume52
Issue number1-4
DOIs
Publication statusPublished - 1994

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