TY - JOUR
T1 - The Effect of Long-term Use of a Dentifrice Containing Zinc Citrate and a Non-ionic Agent on the Oral Flora
AU - Jones, C. L.
AU - Ritchie, J. A.
AU - Marsh, Phillip
AU - Van Der Ouderaa, F.
PY - 1988/1
Y1 - 1988/1
N2 - The effect on the oral ecology of daily use, for seven months, of a dentifrice containing 0.5% (w/w) zinc citrate and a non-ionic agent, i.e., 0.2% (wlw) Triclosan (2,4,4’ -trichloro-2’ -hydroxydiphenyl ether), has been monitored on 13 adult volunteers. Plaque and saliva were sampled monthly and the bacterial flora analyzed. Twenty-six volunteers used a placebo dentifrice as part of their normal oral hygiene for four months to establish the baseline microbial flora. The volunteers were then split into two equal groups: One group continued to use the placebo dentifrice; the other used the dentifrice containing zinc citrate and Triclosan. There was no evidence that seven months’ use of a dentifrice containing 0.5% zinc citrate and 0.2% Triclosan caused shifts in the oral microbial ecology, nor was there any evidence of developing bacterial resistance to Triclosan.
AB - The effect on the oral ecology of daily use, for seven months, of a dentifrice containing 0.5% (w/w) zinc citrate and a non-ionic agent, i.e., 0.2% (wlw) Triclosan (2,4,4’ -trichloro-2’ -hydroxydiphenyl ether), has been monitored on 13 adult volunteers. Plaque and saliva were sampled monthly and the bacterial flora analyzed. Twenty-six volunteers used a placebo dentifrice as part of their normal oral hygiene for four months to establish the baseline microbial flora. The volunteers were then split into two equal groups: One group continued to use the placebo dentifrice; the other used the dentifrice containing zinc citrate and Triclosan. There was no evidence that seven months’ use of a dentifrice containing 0.5% zinc citrate and 0.2% Triclosan caused shifts in the oral microbial ecology, nor was there any evidence of developing bacterial resistance to Triclosan.
UR - http://www.scopus.com/inward/record.url?scp=0023952624&partnerID=8YFLogxK
U2 - 10.1177/00220345880670010901
DO - 10.1177/00220345880670010901
M3 - Article
C2 - 11039044
AN - SCOPUS:0023952624
VL - 67
SP - 46
EP - 50
JO - Journal of Dental Research
JF - Journal of Dental Research
SN - 0022-0345
IS - 1
ER -