The effect of aorticmorphology on peri-operative mortality of ruptured abdominal aortic aneurysm

Janet T. Powell*, Michael J. Sweeting, Matthew M. Thompson, Robert J. Hinchliffe, Ray Ashleigh, Rachel Bell, Roger M. Greenhalgh, Simon G. Thompson, Pinar Ulug

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

52 Citations (Scopus)

Abstract

Aims To investigate whether aneurysmshape and extent, which indicate whether a patient with ruptured abdominal aortic aneurysm (rAAA) is eligible for endovascular repair (EVAR), influence the outcome of both EVAR and open surgical repair. Methods and results The influence of sixmorphological parameters (maximumaortic diameter, aneurysm neck diameter, length and conicality, proximalneckangle, andmaximumcommoniliacdiameter)onmortalityandreinterventionswithin30dayswas investigated in rAAApatients randomized beforemorphological assessment in the ImmediateManagement of the Patientwith Rupture: OpenVersus Endovascular strategies (IMPROVE) trial.Patients with a proven diagnosis ofrAAA,whounderwent repair and had their admission computerized tomography scan submitted to the core laboratory, were included.Among 458 patients (364men,mean age 76 years),who had either EVAR(n = 177) oropen repair (n = 281) started, therewere 155 deaths and 88 re-interventionswithin 30 days of randomization analysed according to a pre-specified plan. The mean maximumaortic diameter was 8.6 cm. There were no substantial correlations between the six morphological variables. Aneurysm neck length was shorter in those undergoing open repair (vs. EVAR). Aneurysm neck length (mean 23.3, SD 16.1 mm) was inversely associated with mortality for open repair and overall: adjusted OR 0.72 (95% CI 0.57, 0.92) for each 16 mm (SD) increase in length. There were no convincing associations of morphological parameters with reinterventions. Conclusion Short aneurysm necks adversely influence mortality afteropen repair ofrAAAand preclude conventionalEVAR. Thismay help explain why observational studies, but not randomized trials, have shown an early survival benefit for EVAR. Clinical trial registration: ISRCTN 48334791.

Original languageEnglish
Pages (from-to)1328-1334
Number of pages7
JournalEuropean Heart Journal
Volume36
Issue number21
DOIs
Publication statusPublished - 1 Jun 2015
Externally publishedYes

Bibliographical note

Publisher Copyright:
© The Author 2014.

Keywords

  • Aneurysm
  • Aorta
  • Imaging
  • Rupture
  • Stent grafts
  • Surgery

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