TY - JOUR
T1 - The effect of alpha irradiation on retention of particles in the rat lung
AU - Collier, C. G.
AU - James, A. C.
AU - Ellender, Michele
PY - 1988
Y1 - 1988
N2 - Lung retention was followed for up to 640 days in groups of rats that had inhaled different amounts of a mixed actinide oxide containing239Pu and241Am, and/or fused aluminosilicate particles (FAP) labelled with57Co.Lung retention of239Pu in the rats exposed at the lowest level (initial lung deposit 0.1 kBq, total alpha activity) was greater than that of57Co, the difference being attributed to faster dissolution of the FAP.At the higher levels of the mixed actinide oxide (2 and 9 kBq, total alpha activity), greater retention of the mixed actinide oxide occurred, and at the highest level greater retention of FAP also occurred, these effects being attributable to impaired clearance resulting from alpha radiation induced lung damage.
AB - Lung retention was followed for up to 640 days in groups of rats that had inhaled different amounts of a mixed actinide oxide containing239Pu and241Am, and/or fused aluminosilicate particles (FAP) labelled with57Co.Lung retention of239Pu in the rats exposed at the lowest level (initial lung deposit 0.1 kBq, total alpha activity) was greater than that of57Co, the difference being attributed to faster dissolution of the FAP.At the higher levels of the mixed actinide oxide (2 and 9 kBq, total alpha activity), greater retention of the mixed actinide oxide occurred, and at the highest level greater retention of FAP also occurred, these effects being attributable to impaired clearance resulting from alpha radiation induced lung damage.
UR - http://www.scopus.com/inward/record.url?scp=85008747859&partnerID=8YFLogxK
U2 - 10.1093/annhyg/32.inhaled_particles_VI.1007
DO - 10.1093/annhyg/32.inhaled_particles_VI.1007
M3 - Article
AN - SCOPUS:85008747859
SN - 0003-4878
VL - 32
SP - 1005
EP - 1015
JO - Annals of Occupational Hygiene
JF - Annals of Occupational Hygiene
IS - inhaled_particles_VI
ER -
