Abstract
Crimean-Congo hemorrhagic fever virus is a risk group 4 pathogen, which mandates the use of maximum containment facilities, often termed biosafety level 4 or containment level 4 when working with infectious materials. Diagnostic and research work involving live viruses in such laboratories is timeconsuming and inconvenient, resulting in delays. Herein, we show that serum neutralizing activity against the virus can be measured in low-containment laboratories using a pseudotyped virus.
Original language | English |
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Pages (from-to) | 205-208 |
Number of pages | 4 |
Journal | Japanese Journal of Infectious Diseases |
Volume | 71 |
Issue number | 3 |
DOIs | |
Publication status | Published - 2018 |
Bibliographical note
Funding Information:Acknowledgments We thank Ms. Momoko Ogata of the National Institute of Infectious Diseases, Japan, for her technical assistance. This work was supported in part by grant for Research on Emerging and Re-emerging Infectious Diseases from the Ministry of Health, Labour and Welfare of Japan (H25-Shinko-Ippan-004), by the Japan Society for the Promotion of Science KAKENHI (Grant Numbers 16K08041 and 25670222), and by the Research Program on Emerging and Re-emerging Infectious Diseases from the Japan Agency for Medical Research and Development (AMED).
Publisher Copyright:
© 2018, National Institute of Health. All rights reserved.
Keywords
- Biosafety level
- Crimean-Congo hemorrhagic fever virus
- Pseudotyped virus