TY - JOUR
T1 - The Biosafety Research Road Map
T2 - The Search for Evidence to Support Practices in the Laboratory-Foot and Mouth Disease Virus
AU - Blacksell, Stuart D.
AU - Dhawan, Sandhya
AU - Kusumoto, Marina
AU - Le, Kim Khanh
AU - Summermatter, Kathrin
AU - O'Keefe, Joseph
AU - Kozlovac, Joseph
AU - Almuhairi, Salama Suhail
AU - Sendow, Indrawati
AU - Scheel, Christina M.
AU - Ahumibe, Anthony
AU - Masuku, Zibusiso M.
AU - Bennett, Allan M.
AU - Kojima, Kazunobu
AU - Harper, David R.
AU - Hamilton, Keith
N1 - Publisher Copyright:
© 2023 SAGE Publications Inc.. All rights reserved.
PY - 2023/12/1
Y1 - 2023/12/1
N2 - Introduction: Foot and mouth disease (FMD) is a highly contagious infection of cloven-hoofed animals. The Biosafety Research RoadMap reviewed scientific literature regarding the foot and mouth disease virus (FMDV). This project aims to identify gaps in the data required to conduct evidence-based biorisk assessments, as described by Blacksell et al., and strengthen control measures appropriate for local and national laboratories. Methods: A literature search was conducted to identify potential gaps in biosafety and focused on five main sections: the route of inoculation/modes of transmission, infectious dose, laboratory-acquired infections, containment releases, and disinfection and decontamination strategies. Results: The available data regarding biosafety knowledge gaps and existing evidence have been collated. Some gaps include the need for more scientific data that identify the specific safety contribution of engineering controls, support requirements for showering out after in vitro laboratory work, and whether a 3- to 5-day quarantine period should be applied to individuals conducting in vitro versus in vivo work. Addressing these gaps will contribute to the remediation and improvement of biosafety and biosecurity systems when working with FMDV.
AB - Introduction: Foot and mouth disease (FMD) is a highly contagious infection of cloven-hoofed animals. The Biosafety Research RoadMap reviewed scientific literature regarding the foot and mouth disease virus (FMDV). This project aims to identify gaps in the data required to conduct evidence-based biorisk assessments, as described by Blacksell et al., and strengthen control measures appropriate for local and national laboratories. Methods: A literature search was conducted to identify potential gaps in biosafety and focused on five main sections: the route of inoculation/modes of transmission, infectious dose, laboratory-acquired infections, containment releases, and disinfection and decontamination strategies. Results: The available data regarding biosafety knowledge gaps and existing evidence have been collated. Some gaps include the need for more scientific data that identify the specific safety contribution of engineering controls, support requirements for showering out after in vitro laboratory work, and whether a 3- to 5-day quarantine period should be applied to individuals conducting in vitro versus in vivo work. Addressing these gaps will contribute to the remediation and improvement of biosafety and biosecurity systems when working with FMDV.
KW - biorisk management
KW - biosafety evidence
KW - biosafety knowledge gap analysis
KW - foot and mouth disease
KW - pathogen characteristics
UR - http://www.scopus.com/inward/record.url?scp=85167888328&partnerID=8YFLogxK
U2 - 10.1089/apb.2022.0041
DO - 10.1089/apb.2022.0041
M3 - Review article
AN - SCOPUS:85167888328
SN - 1535-6760
VL - 28
SP - 199
EP - 215
JO - Applied Biosafety
JF - Applied Biosafety
IS - 4
ER -
