The behaviour of uranium-233 oxide and uranyl-233 nitrate in rats

John R. Cooper; G. Neil Stradling; Hylton Smith; Sandra E. Ham

doi:10.1080/09553008214550461

The behaviour of uranium-233 oxide and uranyl-233 nitrate in rats

John R. Cooper^*, G. Neil Stradling, Hylton Smith, Sandra E. Ham

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

65 Citations (Scopus)

Abstract

²³³UO₂ and ²³³UO₂(NO₃)₂ in aqueous suspension have been administered to rats by pulmonary intubation. The ²³³U associated with the fraction of the ²³³UO₂ less than 4 nm in diameter translocates from lungs to blood at the same rapid rate as ²³³U from ²³³UO₂ (NO₃)₂. Identical reactions with blood plasma and lung fluid were observed whether the ²³³U was administered as <4nm ²³³UO₂ particles or ²³³UO₂(NO₃)₂. It is suggested that oxidation of UO₂ to UO₃ occurs followed by the formation of uranyl ion. In blood plasma, approximately 50 per cent of the ²³³U is bound to transferrin, 25 per cent to citrate and 25 per cent on bicarbonate.

Original language	English
Pages (from-to)	421-433
Number of pages	13
Journal	International Journal of Radiation Biology
Volume	41
Issue number	4
DOIs	https://doi.org/10.1080/09553008214550461
Publication status	Published - 1982

Access to Document

10.1080/09553008214550461

Cite this

@article{14aa4df1f07e49b4b5341b915f43d511,

title = "The behaviour of uranium-233 oxide and uranyl-233 nitrate in rats",

abstract = "233UO2 and 233UO2(NO3)2 in aqueous suspension have been administered to rats by pulmonary intubation. The 233U associated with the fraction of the 233UO2 less than 4 nm in diameter translocates from lungs to blood at the same rapid rate as 233U from 233UO2 (NO3)2. Identical reactions with blood plasma and lung fluid were observed whether the 233U was administered as <4nm 233UO2 particles or 233UO2(NO3)2. It is suggested that oxidation of UO2 to UO3 occurs followed by the formation of uranyl ion. In blood plasma, approximately 50 per cent of the 233U is bound to transferrin, 25 per cent to citrate and 25 per cent on bicarbonate.",

author = "Cooper, {John R.} and Stradling, {G. Neil} and Hylton Smith and Ham, {Sandra E.}",

year = "1982",

doi = "10.1080/09553008214550461",

language = "English",

volume = "41",

pages = "421--433",

journal = "International Journal of Radiation Biology",

issn = "0955-3002",

publisher = "Taylor and Francis",

number = "4",

}

TY - JOUR

T1 - The behaviour of uranium-233 oxide and uranyl-233 nitrate in rats

AU - Cooper, John R.

AU - Stradling, G. Neil

AU - Smith, Hylton

AU - Ham, Sandra E.

PY - 1982

Y1 - 1982

N2 - 233UO2 and 233UO2(NO3)2 in aqueous suspension have been administered to rats by pulmonary intubation. The 233U associated with the fraction of the 233UO2 less than 4 nm in diameter translocates from lungs to blood at the same rapid rate as 233U from 233UO2 (NO3)2. Identical reactions with blood plasma and lung fluid were observed whether the 233U was administered as <4nm 233UO2 particles or 233UO2(NO3)2. It is suggested that oxidation of UO2 to UO3 occurs followed by the formation of uranyl ion. In blood plasma, approximately 50 per cent of the 233U is bound to transferrin, 25 per cent to citrate and 25 per cent on bicarbonate.

AB - 233UO2 and 233UO2(NO3)2 in aqueous suspension have been administered to rats by pulmonary intubation. The 233U associated with the fraction of the 233UO2 less than 4 nm in diameter translocates from lungs to blood at the same rapid rate as 233U from 233UO2 (NO3)2. Identical reactions with blood plasma and lung fluid were observed whether the 233U was administered as <4nm 233UO2 particles or 233UO2(NO3)2. It is suggested that oxidation of UO2 to UO3 occurs followed by the formation of uranyl ion. In blood plasma, approximately 50 per cent of the 233U is bound to transferrin, 25 per cent to citrate and 25 per cent on bicarbonate.

UR - http://www.scopus.com/inward/record.url?scp=0020068311&partnerID=8YFLogxK

U2 - 10.1080/09553008214550461

DO - 10.1080/09553008214550461

M3 - Article

C2 - 6978863

AN - SCOPUS:0020068311

SN - 0955-3002

VL - 41

SP - 421

EP - 433

JO - International Journal of Radiation Biology

JF - International Journal of Radiation Biology

IS - 4

ER -

The behaviour of uranium-233 oxide and uranyl-233 nitrate in rats

Abstract

Access to Document

Other files and links

Fingerprint

Cite this