The appearance of endotoxin following urethral instrumentation

A. J.W. Sim*, A. Christine McCartney

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)


The Limulus amoebocyte lysate test was used to detect the presence of endotoxin in the venous blood of 10 patients following urethral instrumentation. The test was negative in all patients before instrumentation, became positive in 9 immediately after instrumentation and in 1 30 min after instrumentation. In 6 patients endotoxin reappeared between 1.5 h and 4.5 h after instrumentation. All blood samples, cultured aerobically and anaerobically, were sterile. Escherichia coli were cultured from one midstream specimen of urine and from one urethral swab in the same patient taken before instrumentation. There were no significant changes in either pulse rate or axillary temperature following instrumentation.

Original languageEnglish
Pages (from-to)443-445
Number of pages3
JournalBritish Journal of Surgery
Issue number6
Publication statusPublished - Jun 1980
Externally publishedYes


Dive into the research topics of 'The appearance of endotoxin following urethral instrumentation'. Together they form a unique fingerprint.

Cite this