Telomere-like DNA polymorphisms associated with genetic predisposition to acute myeloid leukemia in irradiated CBA mice

A. Silver*, Roger Cox

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

25 Citations (Scopus)

Abstract

There is evidence that interstitial telomere (TTAGGG)(n)-like sequences at chromosome 2 fragile sites play an important role in the somatic events that characterize the earliest phases of radiation-induced acute myeloid leukemia in the CBA/H mouse. Here we show that the highly inbred CBA/H colony unexpectedly contains four genotypic variants for telomere-like sequence arrays and that almost all induced myeloid leukemias derive from one of the variant subpopulations that constitutes ≃20% of the colony. Preliminary evidence on the irregular inheritance patterns for these variant sequences is discussed together with the proposal that one form of these telomere sequence arrays either represents or is closely linked to a locus that influences chromosome 2 breakage patterns in hemopoietic cells following irradiation and, through this, susceptibility to induced myeloid leukemia.

Original languageEnglish
Pages (from-to)1407-1410
Number of pages4
JournalProceedings of the National Academy of Sciences of the United States of America
Volume90
Issue number4
DOIs
Publication statusPublished - 1993

Bibliographical note

Copyright:
Copyright 2007 Elsevier B.V., All rights reserved.

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