Technological approaches for improving vaccination compliance and coverage

Céline Lemoine; Aneesh Thakur; Danina Krajišnik; Romain Guyon; Stephanie Longet; Agnieszka Razim; Sabina Górska; Ivana Pantelić; Tanja Ilić; Ines Nikolić; Ed C. Lavelle; Andrzej Gamian; Snežana Savić; Anita Milicic

doi:10.3390/vaccines8020304

Technological approaches for improving vaccination compliance and coverage

Céline Lemoine, Aneesh Thakur, Danina Krajišnik, Romain Guyon, Stephanie Longet, Agnieszka Razim, Sabina Górska, Ivana Pantelić, Tanja Ilić, Ines Nikolić, Ed C. Lavelle, Andrzej Gamian, Snežana Savić, Anita Milicic^*

^*Corresponding author for this work

NIS: Research & Technical Staff

Research output: Contribution to journal › Review article › peer-review

18 Citations (Scopus)

Abstract

Vaccination has been well recognised as a critically important tool in preventing infectious disease, yet incomplete immunisation coverage remains a major obstacle to achieving disease control and eradication. As medical products for global access, vaccines need to be safe, effective and inexpensive. In line with these goals, continuous improvements of vaccine delivery strategies are necessary to achieve the full potential of immunisation. Novel technologies related to vaccine delivery and route of administration, use of advanced adjuvants and controlled antigen release (single-dose immunisation) approaches are expected to contribute to improved coverage and patient compliance. This review discusses the application of micro-and nano-technologies in the alternative routes of vaccine administration (mucosal and cutaneous vaccination), oral vaccine delivery as well as vaccine encapsulation with the aim of controlled antigen release for single-dose vaccination.

Original language	English
Article number	304
Pages (from-to)	1-29
Number of pages	29
Journal	Vaccines
Volume	8
Issue number	2
DOIs	https://doi.org/10.3390/vaccines8020304
Publication status	Published - Jun 2020

Bibliographical note

Publisher Copyright:
© 2020 by the authors.

Keywords

Adjuvants
Compliance
Cutaneous vaccination
Microfluidics
Mucosal vaccination
Vaccine delivery

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.3390/vaccines8020304

Cite this

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title = "Technological approaches for improving vaccination compliance and coverage",

abstract = "Vaccination has been well recognised as a critically important tool in preventing infectious disease, yet incomplete immunisation coverage remains a major obstacle to achieving disease control and eradication. As medical products for global access, vaccines need to be safe, effective and inexpensive. In line with these goals, continuous improvements of vaccine delivery strategies are necessary to achieve the full potential of immunisation. Novel technologies related to vaccine delivery and route of administration, use of advanced adjuvants and controlled antigen release (single-dose immunisation) approaches are expected to contribute to improved coverage and patient compliance. This review discusses the application of micro-and nano-technologies in the alternative routes of vaccine administration (mucosal and cutaneous vaccination), oral vaccine delivery as well as vaccine encapsulation with the aim of controlled antigen release for single-dose vaccination.",

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year = "2020",

month = jun,

doi = "10.3390/vaccines8020304",

language = "English",

volume = "8",

pages = "1--29",

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AU - Lemoine, Céline

AU - Thakur, Aneesh

AU - Krajišnik, Danina

AU - Guyon, Romain

AU - Longet, Stephanie

AU - Razim, Agnieszka

AU - Górska, Sabina

AU - Pantelić, Ivana

AU - Ilić, Tanja

AU - Nikolić, Ines

AU - Lavelle, Ed C.

AU - Gamian, Andrzej

AU - Savić, Snežana

AU - Milicic, Anita

PY - 2020/6

Y1 - 2020/6

N2 - Vaccination has been well recognised as a critically important tool in preventing infectious disease, yet incomplete immunisation coverage remains a major obstacle to achieving disease control and eradication. As medical products for global access, vaccines need to be safe, effective and inexpensive. In line with these goals, continuous improvements of vaccine delivery strategies are necessary to achieve the full potential of immunisation. Novel technologies related to vaccine delivery and route of administration, use of advanced adjuvants and controlled antigen release (single-dose immunisation) approaches are expected to contribute to improved coverage and patient compliance. This review discusses the application of micro-and nano-technologies in the alternative routes of vaccine administration (mucosal and cutaneous vaccination), oral vaccine delivery as well as vaccine encapsulation with the aim of controlled antigen release for single-dose vaccination.

AB - Vaccination has been well recognised as a critically important tool in preventing infectious disease, yet incomplete immunisation coverage remains a major obstacle to achieving disease control and eradication. As medical products for global access, vaccines need to be safe, effective and inexpensive. In line with these goals, continuous improvements of vaccine delivery strategies are necessary to achieve the full potential of immunisation. Novel technologies related to vaccine delivery and route of administration, use of advanced adjuvants and controlled antigen release (single-dose immunisation) approaches are expected to contribute to improved coverage and patient compliance. This review discusses the application of micro-and nano-technologies in the alternative routes of vaccine administration (mucosal and cutaneous vaccination), oral vaccine delivery as well as vaccine encapsulation with the aim of controlled antigen release for single-dose vaccination.

KW - Adjuvants

KW - Compliance

KW - Cutaneous vaccination

KW - Microfluidics

KW - Mucosal vaccination

KW - Vaccine delivery

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U2 - 10.3390/vaccines8020304

DO - 10.3390/vaccines8020304

M3 - Review article

AN - SCOPUS:85086654488

SN - 2076-393X

VL - 8

SP - 1

EP - 29

JO - Vaccines

JF - Vaccines

IS - 2

M1 - 304

ER -

Technological approaches for improving vaccination compliance and coverage

Abstract

Bibliographical note

Keywords

UN SDGs

Access to Document

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Cite this