Abstract
Tailoring vaccines to the older population (>65 yrs) is an emerging subject that has gained momentum over the past decade. The vaccine efficacy of a formulation administered to young adults is often much higher than in older people. Therefore, there has been a clarion call for vaccines which show improved effectiveness in older individuals. There is substantial evidence indicating that immunosenescence, which is aging of the immune system, causes dysfunction of the immune system and the associated components, which consequently impacts vaccine response. Therefore, vaccines need to be tailored with specific strategies designed to boost immune responses in older people, in order to achieve increased vaccine efficacy. Although several vaccine formulations have already been designed showing improved vaccine efficacy in older people, research into many more strategies is necessary and ongoing, to further enhance protection in the aging population.
| Original language | English |
|---|---|
| Title of host publication | AAPS Advances in the Pharmaceutical Sciences Series |
| Publisher | Springer |
| Pages | 231-285 |
| Number of pages | 55 |
| DOIs | |
| Publication status | Published - 2023 |
Publication series
| Name | AAPS Advances in the Pharmaceutical Sciences Series |
|---|---|
| Volume | 51 |
| ISSN (Print) | 2210-7371 |
| ISSN (Electronic) | 2210-738X |
Bibliographical note
Publisher Copyright:© The Author(s), under exclusive license to Springer Nature Switzerland AG 2023.
Keywords
- Immune system
- Immunosenescence
- Inflammaging
- Older individuals
- Tailored approach
- Vaccine formulations
