Tailoring Vaccines for Older Individuals: Aging of the Immune System and the Impact on Vaccine Efficacy

Shazia Bashir, Maria Wilson, Diane Ashiru-Oredope, Sudaxshina Murdan*

*Corresponding author for this work

    Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


    Tailoring vaccines to the older population (>65 yrs) is an emerging subject that has gained momentum over the past decade. The vaccine efficacy of a formulation administered to young adults is often much higher than in older people. Therefore, there has been a clarion call for vaccines which show improved effectiveness in older individuals. There is substantial evidence indicating that immunosenescence, which is aging of the immune system, causes dysfunction of the immune system and the associated components, which consequently impacts vaccine response. Therefore, vaccines need to be tailored with specific strategies designed to boost immune responses in older people, in order to achieve increased vaccine efficacy. Although several vaccine formulations have already been designed showing improved vaccine efficacy in older people, research into many more strategies is necessary and ongoing, to further enhance protection in the aging population.

    Original languageEnglish
    Title of host publicationAAPS Advances in the Pharmaceutical Sciences Series
    Number of pages55
    Publication statusPublished - 2023

    Publication series

    NameAAPS Advances in the Pharmaceutical Sciences Series
    ISSN (Print)2210-7371
    ISSN (Electronic)2210-738X

    Bibliographical note

    Publisher Copyright:
    © The Author(s), under exclusive license to Springer Nature Switzerland AG 2023.


    • Immune system
    • Immunosenescence
    • Inflammaging
    • Older individuals
    • Tailored approach
    • Vaccine formulations


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