Synopsis of partial-body radiation diagnostic biomarkers and medical management of radiation injury workshop

Pataje G.S. Prasanna, William F. Blakely, Jean Marc Bertho, John P. Chute, Eric P. Cohen, Ronald E. Goans, Marcy B. Grace, Patricia K. Lillis-Hearne, David C. Lloyd, Ludy C.H.W. Lutgens, Viktor Meineke, Natalia I. Ossetrova, Alexander Romanyukha, Julie D. Saba, Daniel J. Weisdorf, Andrzej Wojcik, Eduardo G. Yukihara, Terry C. Pellmar

    Research output: Contribution to journalArticlepeer-review

    48 Citations (Scopus)

    Abstract

    Radiation exposures from accidents, nuclear detonations or terrorist incidents are unlikely to be homogeneous; however, current biodosimetric approaches are developed and validated primarily in whole-body irradiation models. A workshop was held at the Armed Forces Radiobiology Research Institute in May 2008 to draw attention to the need for partial-body biodosimetry, to discuss current knowledge, and to identify the gaps to be filled. A panel of international experts and the workshop attendees discussed the requirements and concepts for a path forward. This report addresses eight key areas identified by the Workshop Program Committee for future focus: (1) improved cytogenetics, (2) clinical signs and symptoms, (3) cutaneous bioindicators, (4) organ-specific biomarkers, (5) biophysical markers of dose, (6) integrated diagnostic approaches, (7) confounding factors, and (8) requirements for post-event medical follow-up. For each area, the status, advantages and limitations of existing approaches and suggestions for new directions are presented.

    Original languageEnglish
    Pages (from-to)245-253
    Number of pages9
    JournalRadiation Research
    Volume173
    Issue number2
    DOIs
    Publication statusPublished - Feb 2010

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