SUsceptibility and Resistance to Fosfomycin and other antimicrobial agents among pathogens causing lower urinary tract infections: findings of the SURF study

Michaela Tutone*, Truls E. Bjerklund Johansen, Tommaso Cai, Shazad Mushtaq, David M. Livermore

*Corresponding author for this work

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3 Citations (Scopus)
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Abstract

Urinary tract infections (UTIs) are prevalent worldwide, particularly among women. Their incidence increases with age, and treatment is increasingly challenging owing to antibiotic resistance and the lack of new agents. We investigated the susceptibility of current urinary isolates to fosfomycin and other antibiotics across Europe. This cross-sectional study collected consecutive urinary isolates from non-hospitalised women at 20 centres in Belgium, the UK, Italy, Spain and Russia. Bacteria were tested by disk diffusion with relevant antibiotics. As a quality control, a central laboratory re-tested, by agar dilution, (i) isolates found resistant to fosfomycin and (ii) every tenth isolate; all non-Russian sites were included. A total of 2848 isolates were analysed, principally Escherichia coli (2064; 72.5%), Klebsiella spp. (275; 9.7%) and Proteus spp. (103; 3.6%). For E. coli, agents active against >90% of isolates were nitrofurantoin (98.5%), fosfomycin (96.4%) and mecillinam (91.8%). Fosfomycin and nitrofurantoin remained active against >90% of cephalosporin-resistant E. coli. Among 143 E. coli recorded as susceptible locally by disk tests, 138 (96.5%) were confirmed susceptible by minimum inhibitory concentration (MIC) tests, however resistance was only confirmed in 29/58 (50.0%) of those reported resistant by local disk tests. Escherichia coli was found to be the most common uropathogen isolated and was highly susceptible to fosfomycin, nitrofurantoin and mecillinam, all used effectively for more than 30 years. Guidelines advocating fosfomycin for uncomplicated UTIs in women remain microbiologically valid.

Original languageEnglish
Article number106574
JournalInternational Journal of Antimicrobial Agents
Volume59
Issue number5
Early online date18 Mar 2022
DOIs
Publication statusPublished - 5 May 2022

Bibliographical note

Funding Information: This study was entirely supported by Zambon SpA, Italy.

DML has participated on advisory boards or provided ad hoc consultancy for Accelerate, Antabio, Centauri, Entasis, GSK, Integra-Holdings, Meiji, Menarini, Mutabilis, Nordic, Paion, ParaPharm, Pfizer, QPEX, Shionogi, Summit/Discuva, Sumitovant, T.A.Z., VenatoRx, Wockhardt and Zambon, has given paid lectures for bioMérieux, Beckman Coulter, Cardiome, GSK, Hikma, Merck/MSD, Menarini, Nordic, Pfizer and Shionogi. Relevant shareholdings include Dechra, GSK, Merck, Pfizer and Perkin Elmer amounting to less than 10% of portfolio value; share options: T.A.Z. DML also has nominated holdings in Avacta, Diaceutics, Evgen, Faron, Genedrive, Poolbeg, Renalytics, Saietta, Synairgen and Verici through Enterprise Investment Schemes but has no authority to trade these shares directly. TEBJ has been an advisory board member and paid lecturer for Zambon and has received consultancy fees from LMTB (Switzerland), Ferrosan (DK), Borregaard (NO) and research funding from Merck (Cubist) through the European Association of Urology Research Foundation. All other authors declare no competing interests.

Open Access: This is an open access article under the CC BY license
(http://creativecommons.org/licenses/by/4.0/).

Publisher Copyright: © 2022 The Authors. Published by Elsevier Ltd.

Citation: Michaela Tutone, Truls E. Bjerklund Johansen, Tommaso Cai, Shazad Mushtaq, David M. Livermore, SUsceptibility and Resistance to Fosfomycin and other antimicrobial agents among pathogens causing lower urinary tract infections: findings of the SURF study, International Journal of Antimicrobial Agents, Volume 59, Issue 5, 2022, 106574, ISSN 0924-8579.

DOI: https://doi.org/10.1016/j.ijantimicag.2022.106574.

Keywords

  • Antibiotic susceptibility
  • Cystitis
  • Escherichia coli
  • Fosfomycin trometamol
  • Urinary tract infection
  • Uropathogen

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