Survival at older ages: Are greater influenza antibody titers protective?

C. Jessica E. Metcalf; Sabra L. Klein; Jonathan M. Read; Steven Riley; Derek Adam T. Cummings; Yi Guan; Kin On Kwok; Huachen Zhu; Chaoqiang Jiang; Tai Hing Lam; Justin Lessler

doi:10.1016/j.mehy.2023.111135

Survival at older ages: Are greater influenza antibody titers protective?

C. Jessica E. Metcalf^*, Sabra L. Klein, Jonathan M. Read, Steven Riley, Derek Adam T. Cummings, Yi Guan, Kin On Kwok, Huachen Zhu, Chaoqiang Jiang, Tai Hing Lam, Justin Lessler

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

Antibodies are a core element of the immune system's defense against infectious diseases. We hypothesize that antibody titres might therefore be an important predictor of survival in older individuals. This is important because biomarkers that robustly measure survival have proved elusive, despite their potential utility in health care settings. We present evidence supporting the hypothesis that influenza antibody titres are associated with overall survival of older individuals, and indicate a role for biological sex in modulating this association. Since antibody titres can be altered by vaccination, these results have important implications for public health policy on influenza control in aging populations.

Original language	English
Article number	111135
Journal	Medical Hypotheses
Volume	178
DOIs	https://doi.org/10.1016/j.mehy.2023.111135
Publication status	Published - Sept 2023
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2023 Elsevier Ltd

Keywords

Biomarker
Immunity
Influenza
Sex difference
Survival

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.mehy.2023.111135

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title = "Survival at older ages: Are greater influenza antibody titers protective?",

abstract = "Antibodies are a core element of the immune system's defense against infectious diseases. We hypothesize that antibody titres might therefore be an important predictor of survival in older individuals. This is important because biomarkers that robustly measure survival have proved elusive, despite their potential utility in health care settings. We present evidence supporting the hypothesis that influenza antibody titres are associated with overall survival of older individuals, and indicate a role for biological sex in modulating this association. Since antibody titres can be altered by vaccination, these results have important implications for public health policy on influenza control in aging populations.",

keywords = "Biomarker, Immunity, Influenza, Sex difference, Survival",

author = "Metcalf, {C. Jessica E.} and Klein, {Sabra L.} and Read, {Jonathan M.} and Steven Riley and Cummings, {Derek Adam T.} and Yi Guan and Kwok, {Kin On} and Huachen Zhu and Chaoqiang Jiang and {Hing Lam}, Tai and Justin Lessler",

note = "Publisher Copyright: {\textcopyright} 2023 Elsevier Ltd",

year = "2023",

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doi = "10.1016/j.mehy.2023.111135",

language = "English",

volume = "178",

journal = "Medical Hypotheses",

issn = "0306-9877",

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TY - JOUR

T1 - Survival at older ages

T2 - Are greater influenza antibody titers protective?

AU - Metcalf, C. Jessica E.

AU - Klein, Sabra L.

AU - Read, Jonathan M.

AU - Riley, Steven

AU - Cummings, Derek Adam T.

AU - Guan, Yi

AU - Kwok, Kin On

AU - Zhu, Huachen

AU - Jiang, Chaoqiang

AU - Hing Lam, Tai

AU - Lessler, Justin

PY - 2023/9

Y1 - 2023/9

N2 - Antibodies are a core element of the immune system's defense against infectious diseases. We hypothesize that antibody titres might therefore be an important predictor of survival in older individuals. This is important because biomarkers that robustly measure survival have proved elusive, despite their potential utility in health care settings. We present evidence supporting the hypothesis that influenza antibody titres are associated with overall survival of older individuals, and indicate a role for biological sex in modulating this association. Since antibody titres can be altered by vaccination, these results have important implications for public health policy on influenza control in aging populations.

AB - Antibodies are a core element of the immune system's defense against infectious diseases. We hypothesize that antibody titres might therefore be an important predictor of survival in older individuals. This is important because biomarkers that robustly measure survival have proved elusive, despite their potential utility in health care settings. We present evidence supporting the hypothesis that influenza antibody titres are associated with overall survival of older individuals, and indicate a role for biological sex in modulating this association. Since antibody titres can be altered by vaccination, these results have important implications for public health policy on influenza control in aging populations.

KW - Biomarker

KW - Immunity

KW - Influenza

KW - Sex difference

KW - Survival

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DO - 10.1016/j.mehy.2023.111135

M3 - Article

AN - SCOPUS:85168351827

SN - 0306-9877

VL - 178

JO - Medical Hypotheses

JF - Medical Hypotheses

M1 - 111135

ER -

Survival at older ages: Are greater influenza antibody titers protective?

Abstract

Bibliographical note

Keywords

UN SDGs

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