Survey of antimicrobial resistance in clinical Burkholderia pseudomallei isolates over two decades in Northeast Thailand

Vanaporn Wuthiekanun, Premjit Amornchai, Natnaree Saiprom, Narisara Chantratita, Wirongrong Chierakul, Gavin C.K.W. Koh, Wipada Chaowagul, Nicholas P.J. Day, Direk Limmathurotsakul*, Sharon J. Peacock

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

65 Citations (Scopus)

Abstract

A 21-year survey conducted in northeast Thailand of antimicrobial resistance to parenteral antimicrobial drugs used to treat melioidosis identified 24/4,021 (0.6%) patients with one or more isolates resistant to ceftazidime (n ∇ 8), amoxicillin-clavulanic acid (n ∇ 4), or both drugs (n ∇ 12). Two cases were identified at admission, and the remainder were detected a median of 15 days after starting antimicrobial therapy. Resistance to carbapenem drugs was not detected. These findings support the current prescribing recommendations for melioidosis.

Original languageEnglish
Pages (from-to)5388-5391
Number of pages4
JournalAntimicrobial Agents and Chemotherapy
Volume55
Issue number11
DOIs
Publication statusPublished - Nov 2011
Externally publishedYes

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