TY - JOUR
T1 - Strong and specific associations between cardiovascular risk factors and white matter micro- and macrostructure in healthy aging
AU - Cam-CAN
AU - Fuhrmann, Delia
AU - Nesbitt, David
AU - Shafto, Meredith
AU - Rowe, James B.
AU - Price, Darren
AU - Gadie, Andrew
AU - Tyler, Lorraine K.
AU - Brayne, Carol
AU - Bullmore, Edward T.
AU - Calder, Andrew C.
AU - Cusack, Rhodri
AU - Dalgleish, Tim
AU - Duncan, John
AU - Henson, Richard N.
AU - Matthews, Fiona E.
AU - Marslen-Wilson, William D.
AU - Shafto, Meredith A.
AU - Campbell, Karen
AU - Cheung, Teresa
AU - Davis, Simon
AU - Geerligs, Linda
AU - Kievit, Rogier
AU - McCarrey, Anna
AU - Mustafa, Abdur
AU - Price, Darren
AU - Samu, David
AU - Taylor, Jason R.
AU - Treder, Matthias
AU - Tsvetanov, Kamen
AU - van Belle, Janna
AU - Williams, Nitin
AU - Bates, Lauren
AU - Emery, Tina
AU - Erzinlioglu, Sharon
AU - Gadie, Andrew
AU - Gerbase, Sofia
AU - Georgieva, Stanimira
AU - Hanley, Claire
AU - Parkin, Beth
AU - Troy, David
AU - Auer, Tibor
AU - Correia, Marta
AU - Gao, Lu
AU - Green, Emma
AU - Henriques, Rafael
AU - Allen, Jodie
AU - Amery, Gillian
AU - Amunts, Liana
AU - Barcroft, Anne
AU - Castle, Amanda
N1 - Funding Information:
The authors would like to thank Carol Brayne, Simon Davis, and Rik Henson for helpful comments on the study design and imaging techniques. DF, DN, JBR, DP, and RAK are supported by the UK Medical Research Council. The Cambridge Centre for Ageing and Neuroscience (Cam-CAN) was supported by the Biotechnology and Biological Sciences Research Council (grant number BB/H008217/1). JBR is supported by the Wellcome Trust (grant number 103838). RAK is supported by the Sir Henry Wellcome Trust (grant number 107392/Z/15/Z) and MRC Programme Grant SUAG/014 RG91365. This project has also received funding from the European Union's Horizon 2020 research and innovation programme (grant agreement number 732592).
Publisher Copyright:
© 2018 The Authors
PY - 2019/2/1
Y1 - 2019/2/1
N2 - Cardiovascular health declines with age, increasing the risk of hypertension and elevated heart rate in middle and old age. Here, we used multivariate techniques to investigate the associations between cardiovascular health (diastolic blood pressure, systolic blood pressure, and heart rate) and white matter macrostructure (lesion volume and number) and microstructure (as measured by diffusion-weighted imaging) in the cross-sectional, population-based Cam-CAN cohort (N = 667, aged 18–88). We found that cardiovascular health and age made approximately similar contributions to white matter health and explained up to 56% of variance therein. Lower diastolic blood pressure, higher systolic blood pressure, and higher heart rate were each strongly, and independently, associated with white matter abnormalities on all indices. Body mass and exercise were associated with white matter health, both directly and indirectly via cardiovascular health. These results highlight the importance of cardiovascular risk factors for white matter health across the adult lifespan and suggest that systolic blood pressure, diastolic blood pressure, and heart rate affect white matter health via separate mechanisms.
AB - Cardiovascular health declines with age, increasing the risk of hypertension and elevated heart rate in middle and old age. Here, we used multivariate techniques to investigate the associations between cardiovascular health (diastolic blood pressure, systolic blood pressure, and heart rate) and white matter macrostructure (lesion volume and number) and microstructure (as measured by diffusion-weighted imaging) in the cross-sectional, population-based Cam-CAN cohort (N = 667, aged 18–88). We found that cardiovascular health and age made approximately similar contributions to white matter health and explained up to 56% of variance therein. Lower diastolic blood pressure, higher systolic blood pressure, and higher heart rate were each strongly, and independently, associated with white matter abnormalities on all indices. Body mass and exercise were associated with white matter health, both directly and indirectly via cardiovascular health. These results highlight the importance of cardiovascular risk factors for white matter health across the adult lifespan and suggest that systolic blood pressure, diastolic blood pressure, and heart rate affect white matter health via separate mechanisms.
KW - Aging
KW - Blood pressure
KW - Cardiovascular health
KW - Diffusion weighted imaging
KW - Heart rate
KW - White matter lesion
UR - http://www.scopus.com/inward/record.url?scp=85056188453&partnerID=8YFLogxK
U2 - 10.1016/j.neurobiolaging.2018.10.005
DO - 10.1016/j.neurobiolaging.2018.10.005
M3 - Article
C2 - 30415127
AN - SCOPUS:85056188453
VL - 74
SP - 46
EP - 55
JO - Neurobiology of Aging
JF - Neurobiology of Aging
SN - 0197-4580
ER -