Stress Response Pathways

Martin O. Leonard; Alice Limonciel; Paul Jennings

doi:10.1007/978-1-4939-0521-8_19

Stress Response Pathways

Martin O. Leonard, Alice Limonciel, Paul Jennings

Toxicology

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

5 Citations (Scopus)

Abstract

A number of pathways have evolved to overcome cellular stress and to maintain cell and tissue homeostasis. Such stressors can be physiological or externally derived. Many of these pathways are governed by transcription factor activation, meaning that a key regulatory event is the transcription of specific downstream genes. These pathways are usually quickly turned on and off and are tightly controlled via specific regulators and negative feedback loops. Stress response pathways are key to toxicological outcomes and their activation can be used to characterize chemical reactivity. Here we describe some of the major stress response pathways and their implications for toxicological assessment in vitro.

Original language	English
Title of host publication	Methods in Pharmacology and Toxicology
Publisher	Humana Press Inc.
Pages	433-458
Number of pages	26
DOIs	https://doi.org/10.1007/978-1-4939-0521-8_19
Publication status	Published - 2014

Publication series

Name	Methods in Pharmacology and Toxicology
Volume	2014
ISSN (Print)	1557-2153
ISSN (Electronic)	1940-6053

Bibliographical note

Publisher Copyright:
© Springer Science+Business Media New York 2014.

Keywords

ATF4
Energy stress response
FOXO
HIF-1 alpha
Inflammation
Metal-responsive transcription factor-1
Nrf2
Nuclear receptors
p53
Stress response pathways
Transcription factor
Unfolded protein response

Access to Document

10.1007/978-1-4939-0521-8_19

Cite this

@inbook{5d2596c7eea447bcac592649295cfcd9,

title = "Stress Response Pathways",

abstract = "A number of pathways have evolved to overcome cellular stress and to maintain cell and tissue homeostasis. Such stressors can be physiological or externally derived. Many of these pathways are governed by transcription factor activation, meaning that a key regulatory event is the transcription of specific downstream genes. These pathways are usually quickly turned on and off and are tightly controlled via specific regulators and negative feedback loops. Stress response pathways are key to toxicological outcomes and their activation can be used to characterize chemical reactivity. Here we describe some of the major stress response pathways and their implications for toxicological assessment in vitro.",

keywords = "ATF4, Energy stress response, FOXO, HIF-1 alpha, Inflammation, Metal-responsive transcription factor-1, Nrf2, Nuclear receptors, p53, Stress response pathways, Transcription factor, Unfolded protein response",

author = "Leonard, {Martin O.} and Alice Limonciel and Paul Jennings",

note = "Publisher Copyright: {\textcopyright} Springer Science+Business Media New York 2014.",

year = "2014",

doi = "10.1007/978-1-4939-0521-8_19",

language = "English",

series = "Methods in Pharmacology and Toxicology",

publisher = "Humana Press Inc.",

pages = "433--458",

booktitle = "Methods in Pharmacology and Toxicology",

}

TY - CHAP

T1 - Stress Response Pathways

AU - Leonard, Martin O.

AU - Limonciel, Alice

AU - Jennings, Paul

N1 - Publisher Copyright: © Springer Science+Business Media New York 2014.

PY - 2014

Y1 - 2014

N2 - A number of pathways have evolved to overcome cellular stress and to maintain cell and tissue homeostasis. Such stressors can be physiological or externally derived. Many of these pathways are governed by transcription factor activation, meaning that a key regulatory event is the transcription of specific downstream genes. These pathways are usually quickly turned on and off and are tightly controlled via specific regulators and negative feedback loops. Stress response pathways are key to toxicological outcomes and their activation can be used to characterize chemical reactivity. Here we describe some of the major stress response pathways and their implications for toxicological assessment in vitro.

AB - A number of pathways have evolved to overcome cellular stress and to maintain cell and tissue homeostasis. Such stressors can be physiological or externally derived. Many of these pathways are governed by transcription factor activation, meaning that a key regulatory event is the transcription of specific downstream genes. These pathways are usually quickly turned on and off and are tightly controlled via specific regulators and negative feedback loops. Stress response pathways are key to toxicological outcomes and their activation can be used to characterize chemical reactivity. Here we describe some of the major stress response pathways and their implications for toxicological assessment in vitro.

KW - ATF4

KW - Energy stress response

KW - FOXO

KW - HIF-1 alpha

KW - Inflammation

KW - Metal-responsive transcription factor-1

KW - Nrf2

KW - Nuclear receptors

KW - p53

KW - Stress response pathways

KW - Transcription factor

KW - Unfolded protein response

UR - http://www.scopus.com/inward/record.url?scp=84930756769&partnerID=8YFLogxK

U2 - 10.1007/978-1-4939-0521-8_19

DO - 10.1007/978-1-4939-0521-8_19

M3 - Chapter

AN - SCOPUS:84930756769

T3 - Methods in Pharmacology and Toxicology

SP - 433

EP - 458

BT - Methods in Pharmacology and Toxicology

PB - Humana Press Inc.

ER -

Stress Response Pathways

Abstract

Publication series

Bibliographical note

Keywords

Access to Document

Other files and links

Fingerprint

Cite this