Streptococcus pneumoniae isolates expressing a capsule with epitopes of both serotypes 6A and 6B

Carmen L. Sheppard; Bruno Pichon; Robert George; Lucinda M.C. Hall

doi:10.1128/CVI.00335-10

Streptococcus pneumoniae isolates expressing a capsule with epitopes of both serotypes 6A and 6B

Carmen L. Sheppard, Bruno Pichon, Robert George, Lucinda M.C. Hall

HCAI and AMR Divisional Office

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

Abstract

Four Streptococcus pneumoniae isolates expressing both 6A and 6B capsular serotypes were detected by a multiplex immunoassay. The sequence of WciP, a GT2-family glycosyltransferase, indicates that point mutation has compromised linkage specificity, allowing two alternative oligosaccharides to be synthesized. This finding highlights that mutation as well as recombination can mediate serotype change.

Original language	English
Pages (from-to)	1820-1822
Number of pages	3
Journal	Clinical and Vaccine Immunology
Volume	17
Issue number	11
DOIs	https://doi.org/10.1128/CVI.00335-10
Publication status	Published - Nov 2010

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title = "Streptococcus pneumoniae isolates expressing a capsule with epitopes of both serotypes 6A and 6B",

abstract = "Four Streptococcus pneumoniae isolates expressing both 6A and 6B capsular serotypes were detected by a multiplex immunoassay. The sequence of WciP, a GT2-family glycosyltransferase, indicates that point mutation has compromised linkage specificity, allowing two alternative oligosaccharides to be synthesized. This finding highlights that mutation as well as recombination can mediate serotype change.",

author = "Sheppard, {Carmen L.} and Bruno Pichon and Robert George and Hall, {Lucinda M.C.}",

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AU - Pichon, Bruno

AU - George, Robert

AU - Hall, Lucinda M.C.

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AB - Four Streptococcus pneumoniae isolates expressing both 6A and 6B capsular serotypes were detected by a multiplex immunoassay. The sequence of WciP, a GT2-family glycosyltransferase, indicates that point mutation has compromised linkage specificity, allowing two alternative oligosaccharides to be synthesized. This finding highlights that mutation as well as recombination can mediate serotype change.

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AN - SCOPUS:78449238527

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EP - 1822

JO - Clinical and Vaccine Immunology

JF - Clinical and Vaccine Immunology

IS - 11

ER -

Streptococcus pneumoniae isolates expressing a capsule with epitopes of both serotypes 6A and 6B

Abstract

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