TY - JOUR
T1 - Stimulation of rat satellite cell myogenesis by inhibitors of ser/thr protein kinases
AU - Lagord, Catherine
AU - Carpentier, Gilles
AU - Leibovitch, Marie Pierre
AU - Gautron, Jean
AU - Martelly, Isabelle
PY - 1993
Y1 - 1993
N2 - Satellite cells are involved in physiological growth and post-traumatic regeneration of adult skeletal muscle fibres. In this study, it is shown that differentiation of primary cultures of rat satellite cells is increased by inhibitors of ser/thr protein kinases such as iso-H7, which both inhibit cAMP-dependent protein kinase (PKA) and protein kinase C (PKC) activities, and HA1004, a PKA inhibitor. These results, showing a preponderant effect of PKA inhibition on myogenesis in vitro, prompted the effects of iso-H7 on muscular regeneration in vivo to be tested. Preliminary results showed that regeneration of rat muscle EDL was improved by iso-H7 treatment.
AB - Satellite cells are involved in physiological growth and post-traumatic regeneration of adult skeletal muscle fibres. In this study, it is shown that differentiation of primary cultures of rat satellite cells is increased by inhibitors of ser/thr protein kinases such as iso-H7, which both inhibit cAMP-dependent protein kinase (PKA) and protein kinase C (PKC) activities, and HA1004, a PKA inhibitor. These results, showing a preponderant effect of PKA inhibition on myogenesis in vitro, prompted the effects of iso-H7 on muscular regeneration in vivo to be tested. Preliminary results showed that regeneration of rat muscle EDL was improved by iso-H7 treatment.
KW - Satellite cells
KW - cAMP-dependent protein kinase
KW - myogenesis
KW - regeneration
UR - https://www.scopus.com/pages/publications/0027738045
U2 - 10.1016/0960-8966(93)90081-T
DO - 10.1016/0960-8966(93)90081-T
M3 - Article
C2 - 8186679
AN - SCOPUS:0027738045
SN - 0960-8966
VL - 3
SP - 379
EP - 383
JO - Neuromuscular Disorders
JF - Neuromuscular Disorders
IS - 5-6
ER -