TY - JOUR
T1 - Stillbirths
T2 - Rates, risk factors, and acceleration towards 2030
AU - Lancet Ending Preventable Stillbirths Series study group
AU - Lancet Stillbirth Epidemiology investigator group
AU - Lawn, Joy E.
AU - Blencowe, Hannah
AU - Waiswa, Peter
AU - Amouzou, Agbessi
AU - Mathers, Colin
AU - Hogan, Dan
AU - Flenady, Vicki
AU - Frøen, J. Frederik
AU - Qureshi, Zeshan U.
AU - Calderwood, Claire
AU - Shiekh, Suhail
AU - Jassir, Fiorella Bianchi
AU - You, Danzhen
AU - McClure, Elizabeth M.
AU - Mathai, Matthews
AU - Cousens, Simon
AU - Kinney, Mary V.
AU - De Bernis, Luc
AU - Heazell, Alexander
AU - Leisher, Susannah Hopkins
AU - Azad, Kishwar
AU - Rahman, Anisur
AU - El-Arifeen, Shams
AU - Day, Louise T.
AU - Saha, Stacy L.
AU - Alam, Shafiul
AU - Wangdi, Sonam
AU - Ilboudo, Tinga Fulbert
AU - Zhu, Jun
AU - Liang, Juan
AU - Mu, Yi
AU - Li, Xiaohong
AU - Zhong, Nanbert
AU - Kyprianou, Theopisti
AU - Allvee, Kärt
AU - Gissler, Mika
AU - Zeitlin, Jennifer
AU - Bah, Abdouli
AU - Jawara, Lamin
AU - Lack, Nicholas
AU - De Maria Herandez, Flor
AU - More, Neena Shah
AU - Nair, Nirmala
AU - Tripathy, Prasanta
AU - Kumar, Rajesh
AU - Newtonraj, Ariarathinam
AU - Kaur, Manmeet
AU - Gupta, Madhu
AU - Varghese, Beena
AU - Isakova, Jelena
N1 - Publisher Copyright:
© 2016 Elsevier Ltd.
PY - 2016/2/6
Y1 - 2016/2/6
N2 - An estimated 2·6 million third trimester stillbirths occurred in 2015 (uncertainty range 2·4-3·0 million). The number of stillbirths has reduced more slowly than has maternal mortality or mortality in children younger than 5 years, which were explicitly targeted in the Millennium Development Goals. The Every Newborn Action Plan has the target of 12 or fewer stillbirths per 1000 births in every country by 2030. 94 mainly high-income countries and upper middle-income countries have already met this target, although with noticeable disparities. At least 56 countries, particularly in Africa and in areas aff ected by confl ict, will have to more than double present progress to reach this target. Most (98%) stillbirths are in low-income and middle-income countries. Improved care at birth is essential to prevent 1·3 million (uncertainty range 1·2-1·6 million) intrapartum stillbirths, end preventable maternal and neonatal deaths, and improve child development. Estimates for stillbirth causation are impeded by various classifi cation systems, but for 18 countries with reliable data, congenital abnormalities account for a median of only 7·4% of stillbirths. Many disorders associated with stillbirths are potentially modifi able and often coexist, such as maternal infections (population attributable fraction: malaria 8·0% and syphilis 7·7%), non-communicable diseases, nutrition and lifestyle factors (each about 10%), and maternal age older than 35 years (6·7%). Prolonged pregnancies contribute to 14·0% of stillbirths. Causal pathways for stillbirth frequently involve impaired placental function, either with fetal growth restriction or preterm labour, or both. Two-thirds of newborns have their births registered. However, less than 5% of neonatal deaths and even fewer stillbirths have death registration. Records and registrations of all births, stillbirths, neonatal, and maternal deaths in a health facility would substantially increase data availability. Improved data alone will not save lives but provide a way to target interventions to reach more than 7000 women every day worldwide who experience the reality of stillbirth.
AB - An estimated 2·6 million third trimester stillbirths occurred in 2015 (uncertainty range 2·4-3·0 million). The number of stillbirths has reduced more slowly than has maternal mortality or mortality in children younger than 5 years, which were explicitly targeted in the Millennium Development Goals. The Every Newborn Action Plan has the target of 12 or fewer stillbirths per 1000 births in every country by 2030. 94 mainly high-income countries and upper middle-income countries have already met this target, although with noticeable disparities. At least 56 countries, particularly in Africa and in areas aff ected by confl ict, will have to more than double present progress to reach this target. Most (98%) stillbirths are in low-income and middle-income countries. Improved care at birth is essential to prevent 1·3 million (uncertainty range 1·2-1·6 million) intrapartum stillbirths, end preventable maternal and neonatal deaths, and improve child development. Estimates for stillbirth causation are impeded by various classifi cation systems, but for 18 countries with reliable data, congenital abnormalities account for a median of only 7·4% of stillbirths. Many disorders associated with stillbirths are potentially modifi able and often coexist, such as maternal infections (population attributable fraction: malaria 8·0% and syphilis 7·7%), non-communicable diseases, nutrition and lifestyle factors (each about 10%), and maternal age older than 35 years (6·7%). Prolonged pregnancies contribute to 14·0% of stillbirths. Causal pathways for stillbirth frequently involve impaired placental function, either with fetal growth restriction or preterm labour, or both. Two-thirds of newborns have their births registered. However, less than 5% of neonatal deaths and even fewer stillbirths have death registration. Records and registrations of all births, stillbirths, neonatal, and maternal deaths in a health facility would substantially increase data availability. Improved data alone will not save lives but provide a way to target interventions to reach more than 7000 women every day worldwide who experience the reality of stillbirth.
UR - http://www.scopus.com/inward/record.url?scp=84959527417&partnerID=8YFLogxK
U2 - 10.1016/S0140-6736(15)00837-5
DO - 10.1016/S0140-6736(15)00837-5
M3 - Review article
C2 - 26794078
AN - SCOPUS:84959527417
SN - 0140-6736
VL - 387
SP - 587
EP - 603
JO - The Lancet
JF - The Lancet
IS - 10018
ER -