TY - JOUR
T1 - Stage–specific incidence trends of renal cancers in the East of England, 1999–2016
AU - Herbert, Annie
AU - Barclay, Matthew E.
AU - Koo, Minjoung M.
AU - Rous, Brian
AU - Greenberg, David C.
AU - Abel, Gary
AU - Lyratzopoulos, Georgios
N1 - Publisher Copyright:
© 2021 The Authors
Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.
PY - 2021/4
Y1 - 2021/4
N2 - Objectives: To determine stage-specific time-trends in renal cancer incidence.Methods: We used population-based East Anglia data 1999-2016 (population similar to 2 million) on 5,456 primary renal cancer diagnoses, estimating stage-specific annual incidence using Poisson regression, allowing for changing time-trends, and adjusting for sex, age, and socioeconomic deprivation.Results: Renal cancer incidence increased from 9.8-16.4 cases per 100,000 during 1999-2016. Incidence of Stage I, II, and III cases increased over time, most steeply for Stage I, with annual Incidence Rate Ratio [IRR] for Stage I of 1.09 (95 % CI 1.07-1.12) during 1999-2010; and 1.03 (1.00-1.05) during 2011-2016. In contrast, the annual incidence of Stage IV renal cancer decreased during most years, IRR of 0.99 (0.98-1.00) during 2003-2016.Conclusion: The findings are consistent with both earlier detection of symptomatic renal cancer and increasing identification of asymptomatic lesions. However, the decreasing incidence of late-stage disease suggests genuine shifts towards earlier diagnosis.
AB - Objectives: To determine stage-specific time-trends in renal cancer incidence.Methods: We used population-based East Anglia data 1999-2016 (population similar to 2 million) on 5,456 primary renal cancer diagnoses, estimating stage-specific annual incidence using Poisson regression, allowing for changing time-trends, and adjusting for sex, age, and socioeconomic deprivation.Results: Renal cancer incidence increased from 9.8-16.4 cases per 100,000 during 1999-2016. Incidence of Stage I, II, and III cases increased over time, most steeply for Stage I, with annual Incidence Rate Ratio [IRR] for Stage I of 1.09 (95 % CI 1.07-1.12) during 1999-2010; and 1.03 (1.00-1.05) during 2011-2016. In contrast, the annual incidence of Stage IV renal cancer decreased during most years, IRR of 0.99 (0.98-1.00) during 2003-2016.Conclusion: The findings are consistent with both earlier detection of symptomatic renal cancer and increasing identification of asymptomatic lesions. However, the decreasing incidence of late-stage disease suggests genuine shifts towards earlier diagnosis.
KW - Cancer
KW - Diagnosis
KW - Renal
KW - Stage
KW - Trends
UR - http://www.scopus.com/inward/record.url?scp=85099684126&partnerID=8YFLogxK
U2 - 10.1016/j.canep.2020.101883
DO - 10.1016/j.canep.2020.101883
M3 - Article
AN - SCOPUS:85099684126
VL - 71
JO - Cancer Epidemiology
JF - Cancer Epidemiology
SN - 1877-7821
M1 - 101883
ER -
