Stage–specific incidence trends of renal cancers in the East of England, 1999–2016

Annie Herbert; Matthew E. Barclay; Minjoung M. Koo; Brian Rous; David C. Greenberg; Gary Abel; Georgios Lyratzopoulos

doi:10.1016/j.canep.2020.101883

Stage–specific incidence trends of renal cancers in the East of England, 1999–2016

Annie Herbert, Matthew E. Barclay, Minjoung M. Koo, Brian Rous, David C. Greenberg, Gary Abel, Georgios Lyratzopoulos^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

Objectives: To determine stage-specific time-trends in renal cancer incidence.

Methods: We used population-based East Anglia data 1999-2016 (population similar to 2 million) on 5,456 primary renal cancer diagnoses, estimating stage-specific annual incidence using Poisson regression, allowing for changing time-trends, and adjusting for sex, age, and socioeconomic deprivation.

Results: Renal cancer incidence increased from 9.8-16.4 cases per 100,000 during 1999-2016. Incidence of Stage I, II, and III cases increased over time, most steeply for Stage I, with annual Incidence Rate Ratio [IRR] for Stage I of 1.09 (95 % CI 1.07-1.12) during 1999-2010; and 1.03 (1.00-1.05) during 2011-2016. In contrast, the annual incidence of Stage IV renal cancer decreased during most years, IRR of 0.99 (0.98-1.00) during 2003-2016.

Conclusion: The findings are consistent with both earlier detection of symptomatic renal cancer and increasing identification of asymptomatic lesions. However, the decreasing incidence of late-stage disease suggests genuine shifts towards earlier diagnosis.

Original language	English
Article number	101883
Number of pages	4
Journal	Cancer Epidemiology
Volume	71
DOIs	https://doi.org/10.1016/j.canep.2020.101883
Publication status	Published - Apr 2021

Bibliographical note

Publisher Copyright:
© 2021 The Authors

Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.

Keywords

Cancer
Diagnosis
Renal
Stage
Trends

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.canep.2020.101883

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@article{736a3854a66d4befba6e7c40cc7e8eae,

title = "Stage–specific incidence trends of renal cancers in the East of England, 1999–2016",

abstract = "Objectives: To determine stage-specific time-trends in renal cancer incidence.Methods: We used population-based East Anglia data 1999-2016 (population similar to 2 million) on 5,456 primary renal cancer diagnoses, estimating stage-specific annual incidence using Poisson regression, allowing for changing time-trends, and adjusting for sex, age, and socioeconomic deprivation.Results: Renal cancer incidence increased from 9.8-16.4 cases per 100,000 during 1999-2016. Incidence of Stage I, II, and III cases increased over time, most steeply for Stage I, with annual Incidence Rate Ratio [IRR] for Stage I of 1.09 (95 % CI 1.07-1.12) during 1999-2010; and 1.03 (1.00-1.05) during 2011-2016. In contrast, the annual incidence of Stage IV renal cancer decreased during most years, IRR of 0.99 (0.98-1.00) during 2003-2016.Conclusion: The findings are consistent with both earlier detection of symptomatic renal cancer and increasing identification of asymptomatic lesions. However, the decreasing incidence of late-stage disease suggests genuine shifts towards earlier diagnosis.",

keywords = "Cancer, Diagnosis, Renal, Stage, Trends",

author = "Annie Herbert and Barclay, {Matthew E.} and Koo, {Minjoung M.} and Brian Rous and Greenberg, {David C.} and Gary Abel and Georgios Lyratzopoulos",

year = "2021",

month = apr,

doi = "10.1016/j.canep.2020.101883",

language = "English",

volume = "71",

journal = "Cancer Epidemiology",

issn = "1877-7821",

publisher = "Elsevier Ltd.",

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TY - JOUR

T1 - Stage–specific incidence trends of renal cancers in the East of England, 1999–2016

AU - Herbert, Annie

AU - Barclay, Matthew E.

AU - Koo, Minjoung M.

AU - Rous, Brian

AU - Greenberg, David C.

AU - Abel, Gary

AU - Lyratzopoulos, Georgios

PY - 2021/4

Y1 - 2021/4

N2 - Objectives: To determine stage-specific time-trends in renal cancer incidence.Methods: We used population-based East Anglia data 1999-2016 (population similar to 2 million) on 5,456 primary renal cancer diagnoses, estimating stage-specific annual incidence using Poisson regression, allowing for changing time-trends, and adjusting for sex, age, and socioeconomic deprivation.Results: Renal cancer incidence increased from 9.8-16.4 cases per 100,000 during 1999-2016. Incidence of Stage I, II, and III cases increased over time, most steeply for Stage I, with annual Incidence Rate Ratio [IRR] for Stage I of 1.09 (95 % CI 1.07-1.12) during 1999-2010; and 1.03 (1.00-1.05) during 2011-2016. In contrast, the annual incidence of Stage IV renal cancer decreased during most years, IRR of 0.99 (0.98-1.00) during 2003-2016.Conclusion: The findings are consistent with both earlier detection of symptomatic renal cancer and increasing identification of asymptomatic lesions. However, the decreasing incidence of late-stage disease suggests genuine shifts towards earlier diagnosis.

AB - Objectives: To determine stage-specific time-trends in renal cancer incidence.Methods: We used population-based East Anglia data 1999-2016 (population similar to 2 million) on 5,456 primary renal cancer diagnoses, estimating stage-specific annual incidence using Poisson regression, allowing for changing time-trends, and adjusting for sex, age, and socioeconomic deprivation.Results: Renal cancer incidence increased from 9.8-16.4 cases per 100,000 during 1999-2016. Incidence of Stage I, II, and III cases increased over time, most steeply for Stage I, with annual Incidence Rate Ratio [IRR] for Stage I of 1.09 (95 % CI 1.07-1.12) during 1999-2010; and 1.03 (1.00-1.05) during 2011-2016. In contrast, the annual incidence of Stage IV renal cancer decreased during most years, IRR of 0.99 (0.98-1.00) during 2003-2016.Conclusion: The findings are consistent with both earlier detection of symptomatic renal cancer and increasing identification of asymptomatic lesions. However, the decreasing incidence of late-stage disease suggests genuine shifts towards earlier diagnosis.

KW - Cancer

KW - Diagnosis

KW - Renal

KW - Stage

KW - Trends

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DO - 10.1016/j.canep.2020.101883

M3 - Article

AN - SCOPUS:85099684126

SN - 1877-7821

VL - 71

JO - Cancer Epidemiology

JF - Cancer Epidemiology

M1 - 101883

ER -

Stage–specific incidence trends of renal cancers in the East of England, 1999–2016

Abstract

Bibliographical note

Keywords

UN SDGs

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