Stage–specific incidence trends of renal cancers in the East of England, 1999–2016

Annie Herbert, Matthew E. Barclay, Minjoung M. Koo, Brian Rous, David C. Greenberg, Gary Abel, Georgios Lyratzopoulos*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)


Objectives: To determine stage-specific time-trends in renal cancer incidence.

Methods: We used population-based East Anglia data 1999-2016 (population similar to 2 million) on 5,456 primary renal cancer diagnoses, estimating stage-specific annual incidence using Poisson regression, allowing for changing time-trends, and adjusting for sex, age, and socioeconomic deprivation.

Results: Renal cancer incidence increased from 9.8-16.4 cases per 100,000 during 1999-2016. Incidence of Stage I, II, and III cases increased over time, most steeply for Stage I, with annual Incidence Rate Ratio [IRR] for Stage I of 1.09 (95 % CI 1.07-1.12) during 1999-2010; and 1.03 (1.00-1.05) during 2011-2016. In contrast, the annual incidence of Stage IV renal cancer decreased during most years, IRR of 0.99 (0.98-1.00) during 2003-2016.

Conclusion: The findings are consistent with both earlier detection of symptomatic renal cancer and increasing identification of asymptomatic lesions. However, the decreasing incidence of late-stage disease suggests genuine shifts towards earlier diagnosis.

Original languageEnglish
Article number101883
Number of pages4
JournalCancer Epidemiology
Publication statusPublished - Apr 2021

Bibliographical note

Publisher Copyright:
© 2021 The Authors

Copyright 2021 Elsevier B.V., All rights reserved.


  • Cancer
  • Diagnosis
  • Renal
  • Stage
  • Trends


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