Sister-chromatid exchanges induced by mitomycin C after acute or chronic exposure of human lymphocytes to a low dose of X-rays

J. E. Moquet; J. S. Prosser; A. A. Edwards; D. C. Lloyd

doi:10.1016/0165-7992(89)90098-5

Sister-chromatid exchanges induced by mitomycin C after acute or chronic exposure of human lymphocytes to a low dose of X-rays

J. E. Moquet, J. S. Prosser^*, A. A. Edwards, D. C. Lloyd

^*Corresponding author for this work

Radiation Effects

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Abstract

Human peripheral blood lymphocytes from 10 male donors were exposed to mitomycin C with and without prior irradiation with 0.01 Gy X-rays. Acute or chronic irradiation of lymphocytes in G₁ resulted in a decrease in the subsequent level of mitomycin C-induced sister-chromatid exchange aberrations. The effect was small (∼ 10%) with evidence of some variability between donors. By contrast no adaptive response was observed if the cells were treated in G₀.

Original language	English
Pages (from-to)	207-213
Number of pages	7
Journal	Mutation Research Letters
Volume	227
Issue number	4
DOIs	https://doi.org/10.1016/0165-7992(89)90098-5
Publication status	Published - Dec 1989

Bibliographical note

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Copyright 2014 Elsevier B.V., All rights reserved.

Keywords

Lymphocytes, human, X-ray exposure
Mitomycin C
Sister-chromatid exchanges

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10.1016/0165-7992(89)90098-5

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title = "Sister-chromatid exchanges induced by mitomycin C after acute or chronic exposure of human lymphocytes to a low dose of X-rays",

abstract = "Human peripheral blood lymphocytes from 10 male donors were exposed to mitomycin C with and without prior irradiation with 0.01 Gy X-rays. Acute or chronic irradiation of lymphocytes in G1 resulted in a decrease in the subsequent level of mitomycin C-induced sister-chromatid exchange aberrations. The effect was small (∼ 10%) with evidence of some variability between donors. By contrast no adaptive response was observed if the cells were treated in G0.",

keywords = "Lymphocytes, human, X-ray exposure, Mitomycin C, Sister-chromatid exchanges",

author = "Moquet, {J. E.} and Prosser, {J. S.} and Edwards, {A. A.} and Lloyd, {D. C.}",

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AU - Moquet, J. E.

AU - Prosser, J. S.

AU - Edwards, A. A.

AU - Lloyd, D. C.

PY - 1989/12

Y1 - 1989/12

N2 - Human peripheral blood lymphocytes from 10 male donors were exposed to mitomycin C with and without prior irradiation with 0.01 Gy X-rays. Acute or chronic irradiation of lymphocytes in G1 resulted in a decrease in the subsequent level of mitomycin C-induced sister-chromatid exchange aberrations. The effect was small (∼ 10%) with evidence of some variability between donors. By contrast no adaptive response was observed if the cells were treated in G0.

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KW - Lymphocytes, human, X-ray exposure

KW - Mitomycin C

KW - Sister-chromatid exchanges

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JF - Mutation Research Letters

IS - 4

ER -

Sister-chromatid exchanges induced by mitomycin C after acute or chronic exposure of human lymphocytes to a low dose of X-rays

Abstract

Bibliographical note

Keywords

UN SDGs

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