Human peripheral blood lymphocytes from 10 male donors were exposed to mitomycin C with and without prior irradiation with 0.01 Gy X-rays. Acute or chronic irradiation of lymphocytes in G1 resulted in a decrease in the subsequent level of mitomycin C-induced sister-chromatid exchange aberrations. The effect was small (∼ 10%) with evidence of some variability between donors. By contrast no adaptive response was observed if the cells were treated in G0.
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- Lymphocytes, human, X-ray exposure
- Mitomycin C
- Sister-chromatid exchanges