Single-nucleotide polymorphism-defined class i and class III major histocompatibility complex genetic subregions contribute to natural long-term nonprogression in HIV infection

J. Guergnon; C. Dalmasso; P. Broet; L. Meyer; S. J. Westrop; N. Imami; E. Vicenzi; G. Morsica; M. Tinelli; B. Zanone Poma; C. Goujard; V. Potard; F. M. Gotch; C. Casoli; A. Cossarizza; F. MacCiardi; P. Debré; J. F. Delfraissy; M. Galli; B. Autran; D. Costagliola; G. Poli; I. Theodorou; A. Riva

doi:10.1093/infdis/jir833

Single-nucleotide polymorphism-defined class i and class III major histocompatibility complex genetic subregions contribute to natural long-term nonprogression in HIV infection

J. Guergnon^*, C. Dalmasso, P. Broet, L. Meyer, S. J. Westrop, N. Imami, E. Vicenzi, G. Morsica, M. Tinelli, B. Zanone Poma, C. Goujard, V. Potard, F. M. Gotch, C. Casoli, A. Cossarizza, F. MacCiardi, P. Debré, J. F. Delfraissy, M. Galli, B. AutranD. Costagliola, G. Poli, I. Theodorou, A. Riva

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

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Abstract

We performed a genome-wide association study comparing a cohort of 144 human immunodeficiency virus (HIV type 1-infected, untreated white long-term nonprogressors (LTNPs) with a cohort of 605 HIV-1-infected white seroconverters. Forty-seven single-nucleotide polymorphisms (SNPs), located from class I to class III major histocompatibility complex (MHC) subregions, show statistical association (false discovery rate, <0.05) with the LTNP condition, among which 5 reached genome-wide significance after Bonferonni correction. The MHC LTNP-associated SNPs are ordered in ≥4 linkage disequilibrium blocks; interestingly, an MHC class III linkage disequilibrium block (defined by the rs9368699 SNP) seems specific to the LTNP phenotype.

Original language	English
Pages (from-to)	718-724
Number of pages	7
Journal	Journal of Infectious Diseases
Volume	205
Issue number	5
DOIs	https://doi.org/10.1093/infdis/jir833
Publication status	Published - 1 Mar 2012
Externally published	Yes

Bibliographical note

Funding Information:
Financial support. This work was supported by the GISHEAL project (http://www.gisheal.eu/index.php, last accessed december 2011) of the 6th Framework Program of the European Commission. Potential conflicts of interest. All authors: No reported conflicts.

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10.1093/infdis/jir833

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Guergnon, J., Dalmasso, C., Broet, P., Meyer, L., Westrop, S. J., Imami, N., Vicenzi, E., Morsica, G., Tinelli, M., Zanone Poma, B., Goujard, C., Potard, V., Gotch, F. M., Casoli, C., Cossarizza, A., MacCiardi, F., Debré, P., Delfraissy, J. F., Galli, M., ... Riva, A. (2012). Single-nucleotide polymorphism-defined class i and class III major histocompatibility complex genetic subregions contribute to natural long-term nonprogression in HIV infection. Journal of Infectious Diseases, 205(5), 718-724. https://doi.org/10.1093/infdis/jir833

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title = "Single-nucleotide polymorphism-defined class i and class III major histocompatibility complex genetic subregions contribute to natural long-term nonprogression in HIV infection",

abstract = "We performed a genome-wide association study comparing a cohort of 144 human immunodeficiency virus (HIV type 1-infected, untreated white long-term nonprogressors (LTNPs) with a cohort of 605 HIV-1-infected white seroconverters. Forty-seven single-nucleotide polymorphisms (SNPs), located from class I to class III major histocompatibility complex (MHC) subregions, show statistical association (false discovery rate, <0.05) with the LTNP condition, among which 5 reached genome-wide significance after Bonferonni correction. The MHC LTNP-associated SNPs are ordered in ≥4 linkage disequilibrium blocks; interestingly, an MHC class III linkage disequilibrium block (defined by the rs9368699 SNP) seems specific to the LTNP phenotype.",

author = "J. Guergnon and C. Dalmasso and P. Broet and L. Meyer and Westrop, {S. J.} and N. Imami and E. Vicenzi and G. Morsica and M. Tinelli and {Zanone Poma}, B. and C. Goujard and V. Potard and Gotch, {F. M.} and C. Casoli and A. Cossarizza and F. MacCiardi and P. Debr{\'e} and Delfraissy, {J. F.} and M. Galli and B. Autran and D. Costagliola and G. Poli and I. Theodorou and A. Riva",

note = "Funding Information: Financial support. This work was supported by the GISHEAL project (http://www.gisheal.eu/index.php, last accessed december 2011) of the 6th Framework Program of the European Commission. Potential conflicts of interest. All authors: No reported conflicts.",

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doi = "10.1093/infdis/jir833",

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Guergnon, J, Dalmasso, C, Broet, P, Meyer, L, Westrop, SJ, Imami, N, Vicenzi, E, Morsica, G, Tinelli, M, Zanone Poma, B, Goujard, C, Potard, V, Gotch, FM, Casoli, C, Cossarizza, A, MacCiardi, F, Debré, P, Delfraissy, JF, Galli, M, Autran, B, Costagliola, D, Poli, G, Theodorou, I & Riva, A 2012, 'Single-nucleotide polymorphism-defined class i and class III major histocompatibility complex genetic subregions contribute to natural long-term nonprogression in HIV infection', Journal of Infectious Diseases, vol. 205, no. 5, pp. 718-724. https://doi.org/10.1093/infdis/jir833

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AU - Guergnon, J.

AU - Dalmasso, C.

AU - Broet, P.

AU - Meyer, L.

AU - Westrop, S. J.

AU - Imami, N.

AU - Vicenzi, E.

AU - Morsica, G.

AU - Tinelli, M.

AU - Zanone Poma, B.

AU - Goujard, C.

AU - Potard, V.

AU - Gotch, F. M.

AU - Casoli, C.

AU - Cossarizza, A.

AU - MacCiardi, F.

AU - Debré, P.

AU - Delfraissy, J. F.

AU - Galli, M.

AU - Autran, B.

AU - Costagliola, D.

AU - Poli, G.

AU - Theodorou, I.

AU - Riva, A.

N1 - Funding Information: Financial support. This work was supported by the GISHEAL project (http://www.gisheal.eu/index.php, last accessed december 2011) of the 6th Framework Program of the European Commission. Potential conflicts of interest. All authors: No reported conflicts.

PY - 2012/3/1

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N2 - We performed a genome-wide association study comparing a cohort of 144 human immunodeficiency virus (HIV type 1-infected, untreated white long-term nonprogressors (LTNPs) with a cohort of 605 HIV-1-infected white seroconverters. Forty-seven single-nucleotide polymorphisms (SNPs), located from class I to class III major histocompatibility complex (MHC) subregions, show statistical association (false discovery rate, <0.05) with the LTNP condition, among which 5 reached genome-wide significance after Bonferonni correction. The MHC LTNP-associated SNPs are ordered in ≥4 linkage disequilibrium blocks; interestingly, an MHC class III linkage disequilibrium block (defined by the rs9368699 SNP) seems specific to the LTNP phenotype.

AB - We performed a genome-wide association study comparing a cohort of 144 human immunodeficiency virus (HIV type 1-infected, untreated white long-term nonprogressors (LTNPs) with a cohort of 605 HIV-1-infected white seroconverters. Forty-seven single-nucleotide polymorphisms (SNPs), located from class I to class III major histocompatibility complex (MHC) subregions, show statistical association (false discovery rate, <0.05) with the LTNP condition, among which 5 reached genome-wide significance after Bonferonni correction. The MHC LTNP-associated SNPs are ordered in ≥4 linkage disequilibrium blocks; interestingly, an MHC class III linkage disequilibrium block (defined by the rs9368699 SNP) seems specific to the LTNP phenotype.

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SN - 0022-1899

VL - 205

SP - 718

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JO - Journal of Infectious Diseases

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ER -

Single-nucleotide polymorphism-defined class i and class III major histocompatibility complex genetic subregions contribute to natural long-term nonprogression in HIV infection

Abstract

Bibliographical note

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