Abstract
Purpose: To check whether simple chromosome exchanges are linearly related to radiation dose. Materials and methods: G(o)-irradiated lymphocytes were cultured to produce metaphase preparations. Chromosomes 1 and 2 were painted different colours and the remaining chromosomes counterstained. Cells containing a colour junction involving both chromosomes 1 and 2 were scored fully, so that simple and complex rearrangements were distinguished. Results: At doses of 2 Gy and below very few complex rearrangements were seen. About 90% of exchanges were simple. At these doses the linear component of the dose-effect curve accounts on average for only ~30% of the observed yield. Conclusions: There is a square-law dose component to the yield of simple exchanges in addition to the linear term.
Original language | English |
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Pages (from-to) | 1113-1117 |
Number of pages | 5 |
Journal | International Journal of Radiation Biology |
Volume | 75 |
Issue number | 9 |
DOIs | |
Publication status | Published - 1999 |
Bibliographical note
Funding Information:This work was partly supported by a CEC research Contract no. F14P CT9050. Th1e au1thorcs are indebted to Dr Paul Simpson, Medical Research Council’s Radiation and Genome Stability Unit, for access to his primary data sheets to enable the comparisons to be drawn with the present data.