Sickle cell disease and thalassaemia antenatal screening programme in England over 10 years: A review from 2007/2008 to 2016/2017

Leonora G. Weil*, Matthew R.M. Charlton, Cathy Coppinger, Yvonne Daniel, Allison Streetly

*Corresponding author for this work

    Research output: Contribution to journalReview articlepeer-review

    11 Citations (Scopus)

    Abstract

    Objectives To evaluate the antenatal sickle cell and thalassaemia screening programme in England over 10 years from 1 April 2007 to 31 March 2017. Methods Four routine data sources were used: Antenatal screening laboratory data; key performance indicator data from maternity trusts; prenatal diagnosis (PND) laboratory data and data from screening incidents. Results For the 10 years examined a total of 6608 575 booking samples were reported as screened, and 154 196 pregnant women required further testing. There were 3941 reported PND tests of which there were 964 affected fetal results. Antenatal test coverage and Family Origin Questionnaire completion rates are high and increasing; the proportion of tests declined has decreased. However, there is wide variation in the timing of antenatal tests and completeness of follow-up and testing. Since 2014/2015 a lower proportion of PND tests are performed by the programme standard of 12+6 weeks. Results suggest that PND timing affects reproductive choices as those with an affected fetus identified by PND testing earlier are more likely to terminate the pregnancy. Conclusions The screening programme appears to be widely accepted as part of routine antenatal care in England. However, the timeliness of screening and subsequent PND testing has consistently not met programme standards. Improving timeliness would enable individuals to consider their options to make informed choices for their pregnancies at the appropriate time. This paper reports carrier rates for an almost complete cohort of women which provides important epidemiological information on the genetic profile of women in England.

    Original languageEnglish
    Pages (from-to)183-190
    Number of pages8
    JournalJournal of Clinical Pathology
    Volume73
    Issue number4
    DOIs
    Publication statusPublished - 1 Apr 2020

    Bibliographical note

    Publisher Copyright:
    © 2020 Author(s).

    Keywords

    • diagnostic screening
    • haematology
    • sickle cell disease
    • thalassaemia

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