TY - JOUR
T1 - Short report
T2 - Thrombocytopenia in falciparum malaria is associated with high concentrations of IL-10
AU - Casals-Pascual, Climent
AU - Kai, Oscar
AU - Newton, Charles R.J.C.
AU - Peshu, Norbert
AU - Roberts, David J.
PY - 2006
Y1 - 2006
N2 - Over the last decade, a number of observations have suggested that platelets may play a role in the pathophysiology of severe malaria. However, somewhat paradoxically, thrombocytopenia is not associated clearly with outcome. We studied the relationship between thrombocytopenia and cytokines in Kenyan children with severe malaria and showed that thrombocytopenia (platelet count < 150 × 109/L) strongly correlates with high levels of interleukin (IL)-10. Several studies have shown that high levels of IL-10 are associated with a favorable outcome in severe malaria. Taken together, these data suggest why thrombocytopenia has a complex relationship with severe disease and suggest one mechanism whereby IL-10 may modify the outcome of severe disease.
AB - Over the last decade, a number of observations have suggested that platelets may play a role in the pathophysiology of severe malaria. However, somewhat paradoxically, thrombocytopenia is not associated clearly with outcome. We studied the relationship between thrombocytopenia and cytokines in Kenyan children with severe malaria and showed that thrombocytopenia (platelet count < 150 × 109/L) strongly correlates with high levels of interleukin (IL)-10. Several studies have shown that high levels of IL-10 are associated with a favorable outcome in severe malaria. Taken together, these data suggest why thrombocytopenia has a complex relationship with severe disease and suggest one mechanism whereby IL-10 may modify the outcome of severe disease.
UR - http://www.scopus.com/inward/record.url?scp=33750590155&partnerID=8YFLogxK
U2 - 10.4269/ajtmh.2006.75.434
DO - 10.4269/ajtmh.2006.75.434
M3 - Article
C2 - 16968917
AN - SCOPUS:33750590155
SN - 0002-9637
VL - 75
SP - 434
EP - 436
JO - American Journal of Tropical Medicine and Hygiene
JF - American Journal of Tropical Medicine and Hygiene
IS - 3
ER -
