Short communication: Impact of long-term (14 years) bi-annual ivermectin treatment on Wuchereria bancrofti microfilaraemia

D. Kyelem; J. Medlock; S. Sanou; M. Bonkoungou; B. Boatin; D. H. Molyneux

doi:10.1111/j.1365-3156.2005.01489.x

Short communication: Impact of long-term (14 years) bi-annual ivermectin treatment on Wuchereria bancrofti microfilaraemia

D. Kyelem, J. Medlock, S. Sanou, M. Bonkoungou, B. Boatin, D. H. Molyneux^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

28 Citations (Scopus)

Abstract

Ivermectin has been and continues to be extensively used to control onchocerciasis in areas of hyper and mesoendemicity within the African Programme of Onchocerciasis Control. As programmes to eliminate lymphatic filariasis (LF) caused by Wuchereria bancrofti expand, areas of coendemicity with onchocerciasis will be incorporated into LF programmes. This study reports that in villages which were hyperendemic for onchocerciasis after some 14 years of treatment with ivermectin, no W. bancrofti could be detected in a population of 1210 individuals whilst in adjacent villages a prevalence of around 3% was found. Despite the long period of ivermectin treatment Mansonella perstans did not appear to respond to ivermectin in this setting.

Original language	English
Pages (from-to)	1002-1004
Number of pages	3
Journal	Tropical Medicine and International Health
Volume	10
Issue number	10
DOIs	https://doi.org/10.1111/j.1365-3156.2005.01489.x
Publication status	Published - Oct 2005
Externally published	Yes

Keywords

Ivermectin
Mansonella perstans
Onchocerciasis
Wuchereria bancrofti

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/j.1365-3156.2005.01489.x

Cite this

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title = "Short communication: Impact of long-term (14 years) bi-annual ivermectin treatment on Wuchereria bancrofti microfilaraemia",

abstract = "Ivermectin has been and continues to be extensively used to control onchocerciasis in areas of hyper and mesoendemicity within the African Programme of Onchocerciasis Control. As programmes to eliminate lymphatic filariasis (LF) caused by Wuchereria bancrofti expand, areas of coendemicity with onchocerciasis will be incorporated into LF programmes. This study reports that in villages which were hyperendemic for onchocerciasis after some 14 years of treatment with ivermectin, no W. bancrofti could be detected in a population of 1210 individuals whilst in adjacent villages a prevalence of around 3% was found. Despite the long period of ivermectin treatment Mansonella perstans did not appear to respond to ivermectin in this setting.",

keywords = "Ivermectin, Mansonella perstans, Onchocerciasis, Wuchereria bancrofti",

author = "D. Kyelem and J. Medlock and S. Sanou and M. Bonkoungou and B. Boatin and Molyneux, {D. H.}",

year = "2005",

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doi = "10.1111/j.1365-3156.2005.01489.x",

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T2 - Impact of long-term (14 years) bi-annual ivermectin treatment on Wuchereria bancrofti microfilaraemia

AU - Kyelem, D.

AU - Medlock, J.

AU - Sanou, S.

AU - Bonkoungou, M.

AU - Boatin, B.

AU - Molyneux, D. H.

PY - 2005/10

Y1 - 2005/10

N2 - Ivermectin has been and continues to be extensively used to control onchocerciasis in areas of hyper and mesoendemicity within the African Programme of Onchocerciasis Control. As programmes to eliminate lymphatic filariasis (LF) caused by Wuchereria bancrofti expand, areas of coendemicity with onchocerciasis will be incorporated into LF programmes. This study reports that in villages which were hyperendemic for onchocerciasis after some 14 years of treatment with ivermectin, no W. bancrofti could be detected in a population of 1210 individuals whilst in adjacent villages a prevalence of around 3% was found. Despite the long period of ivermectin treatment Mansonella perstans did not appear to respond to ivermectin in this setting.

AB - Ivermectin has been and continues to be extensively used to control onchocerciasis in areas of hyper and mesoendemicity within the African Programme of Onchocerciasis Control. As programmes to eliminate lymphatic filariasis (LF) caused by Wuchereria bancrofti expand, areas of coendemicity with onchocerciasis will be incorporated into LF programmes. This study reports that in villages which were hyperendemic for onchocerciasis after some 14 years of treatment with ivermectin, no W. bancrofti could be detected in a population of 1210 individuals whilst in adjacent villages a prevalence of around 3% was found. Despite the long period of ivermectin treatment Mansonella perstans did not appear to respond to ivermectin in this setting.

KW - Ivermectin

KW - Mansonella perstans

KW - Onchocerciasis

KW - Wuchereria bancrofti

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Short communication: Impact of long-term (14 years) bi-annual ivermectin treatment on Wuchereria bancrofti microfilaraemia

Abstract

Keywords

UN SDGs

Access to Document

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