Shiga toxin-producing Escherichia coli O157 associated with human infections in Switzerland, 2000-2009

U. Käppeli; H. Hächler; N. Giezendanner; Thomas Cheasty; R. Stephan

doi:10.1017/S0950268810002190

Shiga toxin-producing Escherichia coli O157 associated with human infections in Switzerland, 2000-2009

U. Käppeli, H. Hächler, N. Giezendanner, Thomas Cheasty, R. Stephan^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

Abstract

Shiga toxin-producing Escherichia coli (STEC), an important foodborne pathogen, can cause mild to severe bloody diarrhoea (BD), sometimes followed by life-threatening complications such as haemolytic uraemic syndrome (HUS). A total of 44 O157 strains isolated from different patients from 2000 through 2009 in Switzerland were further characterized and linked to medical history data. Non-bloody diarrhoea was experienced by 15.9%, BD by 61.4% of the patients, and 29.5% developed HUS. All strains belonged to MLST type 11, were positive for stx2 variants (stx2 and/or stx2c), eae and ehxA, and only two strains showed antibiotic resistance. Of the 44 strains, nine phage types (PTs) were detected the most frequent being PT32 (43.2%) and PT8 (18.2%). By PFGE, 39 different patterns were found. This high genetic diversity within the strains leads to the conclusion that STEC O157 infections in Switzerland most often occur as sporadic cases.

Original language	English
Pages (from-to)	1097-1104
Number of pages	8
Journal	Epidemiology and Infection
Volume	139
Issue number	7
DOIs	https://doi.org/10.1017/S0950268810002190
Publication status	Published - Jul 2011

Keywords

Characteristics
STEC O157
epidemiology
human infection

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1017/S0950268810002190

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title = "Shiga toxin-producing Escherichia coli O157 associated with human infections in Switzerland, 2000-2009",

abstract = "Shiga toxin-producing Escherichia coli (STEC), an important foodborne pathogen, can cause mild to severe bloody diarrhoea (BD), sometimes followed by life-threatening complications such as haemolytic uraemic syndrome (HUS). A total of 44 O157 strains isolated from different patients from 2000 through 2009 in Switzerland were further characterized and linked to medical history data. Non-bloody diarrhoea was experienced by 15.9\%, BD by 61.4\% of the patients, and 29.5\% developed HUS. All strains belonged to MLST type 11, were positive for stx2 variants (stx2 and/or stx2c), eae and ehxA, and only two strains showed antibiotic resistance. Of the 44 strains, nine phage types (PTs) were detected the most frequent being PT32 (43.2\%) and PT8 (18.2\%). By PFGE, 39 different patterns were found. This high genetic diversity within the strains leads to the conclusion that STEC O157 infections in Switzerland most often occur as sporadic cases.",

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T1 - Shiga toxin-producing Escherichia coli O157 associated with human infections in Switzerland, 2000-2009

AU - Käppeli, U.

AU - Hächler, H.

AU - Giezendanner, N.

AU - Cheasty, Thomas

AU - Stephan, R.

PY - 2011/7

Y1 - 2011/7

N2 - Shiga toxin-producing Escherichia coli (STEC), an important foodborne pathogen, can cause mild to severe bloody diarrhoea (BD), sometimes followed by life-threatening complications such as haemolytic uraemic syndrome (HUS). A total of 44 O157 strains isolated from different patients from 2000 through 2009 in Switzerland were further characterized and linked to medical history data. Non-bloody diarrhoea was experienced by 15.9%, BD by 61.4% of the patients, and 29.5% developed HUS. All strains belonged to MLST type 11, were positive for stx2 variants (stx2 and/or stx2c), eae and ehxA, and only two strains showed antibiotic resistance. Of the 44 strains, nine phage types (PTs) were detected the most frequent being PT32 (43.2%) and PT8 (18.2%). By PFGE, 39 different patterns were found. This high genetic diversity within the strains leads to the conclusion that STEC O157 infections in Switzerland most often occur as sporadic cases.

AB - Shiga toxin-producing Escherichia coli (STEC), an important foodborne pathogen, can cause mild to severe bloody diarrhoea (BD), sometimes followed by life-threatening complications such as haemolytic uraemic syndrome (HUS). A total of 44 O157 strains isolated from different patients from 2000 through 2009 in Switzerland were further characterized and linked to medical history data. Non-bloody diarrhoea was experienced by 15.9%, BD by 61.4% of the patients, and 29.5% developed HUS. All strains belonged to MLST type 11, were positive for stx2 variants (stx2 and/or stx2c), eae and ehxA, and only two strains showed antibiotic resistance. Of the 44 strains, nine phage types (PTs) were detected the most frequent being PT32 (43.2%) and PT8 (18.2%). By PFGE, 39 different patterns were found. This high genetic diversity within the strains leads to the conclusion that STEC O157 infections in Switzerland most often occur as sporadic cases.

KW - Characteristics

KW - STEC O157

KW - epidemiology

KW - human infection

UR - https://www.scopus.com/pages/publications/85027943106

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DO - 10.1017/S0950268810002190

M3 - Article

AN - SCOPUS:85027943106

SN - 0950-2688

VL - 139

SP - 1097

EP - 1104

JO - Epidemiology and Infection

JF - Epidemiology and Infection

IS - 7

ER -

Shiga toxin-producing Escherichia coli O157 associated with human infections in Switzerland, 2000-2009

Abstract

Keywords

UN SDGs

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