Shiga toxin-producing Escherichia coli O157 associated with human infections in Switzerland, 2000-2009

U. Käppeli, H. Hächler, N. Giezendanner, Thomas Cheasty, R. Stephan*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

16 Citations (Scopus)

Abstract

Shiga toxin-producing Escherichia coli (STEC), an important foodborne pathogen, can cause mild to severe bloody diarrhoea (BD), sometimes followed by life-threatening complications such as haemolytic uraemic syndrome (HUS). A total of 44 O157 strains isolated from different patients from 2000 through 2009 in Switzerland were further characterized and linked to medical history data. Non-bloody diarrhoea was experienced by 15.9%, BD by 61.4% of the patients, and 29.5% developed HUS. All strains belonged to MLST type 11, were positive for stx2 variants (stx2 and/or stx2c), eae and ehxA, and only two strains showed antibiotic resistance. Of the 44 strains, nine phage types (PTs) were detected the most frequent being PT32 (43.2%) and PT8 (18.2%). By PFGE, 39 different patterns were found. This high genetic diversity within the strains leads to the conclusion that STEC O157 infections in Switzerland most often occur as sporadic cases.

Original languageEnglish
Pages (from-to)1097-1104
Number of pages8
JournalEpidemiology and Infection
Volume139
Issue number7
DOIs
Publication statusPublished - Jul 2011

Keywords

  • Characteristics
  • epidemiology
  • human infection
  • STEC O157

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