SF3B1 mutations induce R-loop accumulation and DNA damage in MDS and leukemia cells with therapeutic implications

Shalini Singh; Doaa Ahmed; Hamid Dolatshad; Dharamveer Tatwavedi; Ulrike Schulze; Andrea Sanchi; Sarah Ryley; Ashish Dhir; Lee Carpenter; Suzanne M. Watt; David J. Roberts; Amal M. Abdel-Aal; Sohair K. Sayed; Somaia A. Mohamed; Anna Schuh; Paresh Vyas; Sally Killick; Andriana G. Kotini; Eirini P. Papapetrou; Daniel H. Wiseman; Andrea Pellagatti; Jacqueline Boultwood

doi:10.1038/s41375-020-0753-9

SF3B1 mutations induce R-loop accumulation and DNA damage in MDS and leukemia cells with therapeutic implications

Shalini Singh, Doaa Ahmed, Hamid Dolatshad, Dharamveer Tatwavedi, Ulrike Schulze, Andrea Sanchi, Sarah Ryley, Ashish Dhir, Lee Carpenter, Suzanne M. Watt, David J. Roberts, Amal M. Abdel-Aal, Sohair K. Sayed, Somaia A. Mohamed, Anna Schuh, Paresh Vyas, Sally Killick, Andriana G. Kotini, Eirini P. Papapetrou, Daniel H. WisemanAndrea Pellagatti^*, Jacqueline Boultwood^*

^*Corresponding author for this work

Research output: Contribution to journal › Letter › peer-review

66 Citations (Scopus)

Original language	English
Pages (from-to)	2525-2530
Number of pages	6
Journal	Leukemia
Volume	34
Issue number	9
DOIs	https://doi.org/10.1038/s41375-020-0753-9
Publication status	Published - 1 Sept 2020
Externally published	Yes

Bibliographical note

Funding Information:
Acknowledgements This work was supported by Bloodwise (grant 13042) and by Leukaemia UK (grant PG17/002). We acknowledge Dr Christoffer Lagerholm and Dr Jana Koth for assistance with microscopy. We are grateful to Professor Thomas Webb (SRI International, Menlo Park, CA) and St. Jude Children’s Research Hospital (Memphis, TN) for kindly providing Sudemycin D6. We thank Dr Juan Carlos Izpisua Belmonte (The Salk Institute for Biological Studies, La Jolla, CA) for kindly gifting us the empty ppyCAG expression vector.

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10.1038/s41375-020-0753-9

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Singh, S., Ahmed, D., Dolatshad, H., Tatwavedi, D., Schulze, U., Sanchi, A., Ryley, S., Dhir, A., Carpenter, L., Watt, S. M., Roberts, D. J., Abdel-Aal, A. M., Sayed, S. K., Mohamed, S. A., Schuh, A., Vyas, P., Killick, S., Kotini, A. G., Papapetrou, E. P., ... Boultwood, J. (2020). SF3B1 mutations induce R-loop accumulation and DNA damage in MDS and leukemia cells with therapeutic implications. Leukemia, 34(9), 2525-2530. https://doi.org/10.1038/s41375-020-0753-9

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title = "SF3B1 mutations induce R-loop accumulation and DNA damage in MDS and leukemia cells with therapeutic implications",

author = "Shalini Singh and Doaa Ahmed and Hamid Dolatshad and Dharamveer Tatwavedi and Ulrike Schulze and Andrea Sanchi and Sarah Ryley and Ashish Dhir and Lee Carpenter and Watt, {Suzanne M.} and Roberts, {David J.} and Abdel-Aal, {Amal M.} and Sayed, {Sohair K.} and Mohamed, {Somaia A.} and Anna Schuh and Paresh Vyas and Sally Killick and Kotini, {Andriana G.} and Papapetrou, {Eirini P.} and Wiseman, {Daniel H.} and Andrea Pellagatti and Jacqueline Boultwood",

note = "Funding Information: Acknowledgements This work was supported by Bloodwise (grant 13042) and by Leukaemia UK (grant PG17/002). We acknowledge Dr Christoffer Lagerholm and Dr Jana Koth for assistance with microscopy. We are grateful to Professor Thomas Webb (SRI International, Menlo Park, CA) and St. Jude Children{\textquoteright}s Research Hospital (Memphis, TN) for kindly providing Sudemycin D6. We thank Dr Juan Carlos Izpisua Belmonte (The Salk Institute for Biological Studies, La Jolla, CA) for kindly gifting us the empty ppyCAG expression vector.",

year = "2020",

month = sep,

day = "1",

doi = "10.1038/s41375-020-0753-9",

language = "English",

volume = "34",

pages = "2525--2530",

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Singh, S, Ahmed, D, Dolatshad, H, Tatwavedi, D, Schulze, U, Sanchi, A, Ryley, S, Dhir, A, Carpenter, L, Watt, SM, Roberts, DJ, Abdel-Aal, AM, Sayed, SK, Mohamed, SA, Schuh, A, Vyas, P, Killick, S, Kotini, AG, Papapetrou, EP, Wiseman, DH, Pellagatti, A & Boultwood, J 2020, 'SF3B1 mutations induce R-loop accumulation and DNA damage in MDS and leukemia cells with therapeutic implications', Leukemia, vol. 34, no. 9, pp. 2525-2530. https://doi.org/10.1038/s41375-020-0753-9

TY - JOUR

T1 - SF3B1 mutations induce R-loop accumulation and DNA damage in MDS and leukemia cells with therapeutic implications

AU - Singh, Shalini

AU - Ahmed, Doaa

AU - Dolatshad, Hamid

AU - Tatwavedi, Dharamveer

AU - Schulze, Ulrike

AU - Sanchi, Andrea

AU - Ryley, Sarah

AU - Dhir, Ashish

AU - Carpenter, Lee

AU - Watt, Suzanne M.

AU - Roberts, David J.

AU - Abdel-Aal, Amal M.

AU - Sayed, Sohair K.

AU - Mohamed, Somaia A.

AU - Schuh, Anna

AU - Vyas, Paresh

AU - Killick, Sally

AU - Kotini, Andriana G.

AU - Papapetrou, Eirini P.

AU - Wiseman, Daniel H.

AU - Pellagatti, Andrea

AU - Boultwood, Jacqueline

N1 - Funding Information: Acknowledgements This work was supported by Bloodwise (grant 13042) and by Leukaemia UK (grant PG17/002). We acknowledge Dr Christoffer Lagerholm and Dr Jana Koth for assistance with microscopy. We are grateful to Professor Thomas Webb (SRI International, Menlo Park, CA) and St. Jude Children’s Research Hospital (Memphis, TN) for kindly providing Sudemycin D6. We thank Dr Juan Carlos Izpisua Belmonte (The Salk Institute for Biological Studies, La Jolla, CA) for kindly gifting us the empty ppyCAG expression vector.

PY - 2020/9/1

Y1 - 2020/9/1

UR - http://www.scopus.com/inward/record.url?scp=85079799511&partnerID=8YFLogxK

U2 - 10.1038/s41375-020-0753-9

DO - 10.1038/s41375-020-0753-9

M3 - Letter

C2 - 32076118

AN - SCOPUS:85079799511

SN - 0887-6924

VL - 34

SP - 2525

EP - 2530

JO - Leukemia

JF - Leukemia

IS - 9

ER -

SF3B1 mutations induce R-loop accumulation and DNA damage in MDS and leukemia cells with therapeutic implications

Bibliographical note

UN SDGs

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