Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Placental Infection Is Associated With Massive Perivillous Fibrin Deposition at the Maternal-Fetal Interface: A Preliminary Study

Esin Kotiloglu-Karaa; Beatrix Kele; Raghavendran Kulasegaran-Shylini; Claire E. Broad; Dola Owoyemi; Joanne Martin; Graham MacPhail; Stamatina Iliodromiti; Anna Riddell; Eliza Alexander; Teresa Cutino-Moguel

doi:10.1093/cid/ciac173

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Placental Infection Is Associated With Massive Perivillous Fibrin Deposition at the Maternal-Fetal Interface: A Preliminary Study

Esin Kotiloglu-Karaa, Beatrix Kele, Raghavendran Kulasegaran-Shylini, Claire E. Broad, Dola Owoyemi, Joanne Martin, Graham MacPhail, Stamatina Iliodromiti, Anna Riddell, Eliza Alexander, Teresa Cutino-Moguel^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

We observed an increased frequency of massive perivillous fibrin deposition (MPFD) during the second coronavirus disease 2019 (COVID-19) pandemic wave dominated by the Alpha variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). MPFD associated with 100% reverse transcription polymerase chain reaction (RT-PCR) positivity for SARS-CoV-2 and detection by immunohistochemistry. The Alpha variant was identified in all placentas with MPFD that could be sequenced.

Original language	English
Pages (from-to)	E1176-E1179
Journal	Clinical Infectious Diseases
Volume	75
Issue number	1
DOIs	https://doi.org/10.1093/cid/ciac173
Publication status	Published - 1 Jul 2022
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2022 The Author(s). Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved.

Keywords

2
CoV
SARS
fibrin deposition
placenta

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1093/cid/ciac173

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Kotiloglu-Karaa, E., Kele, B., Kulasegaran-Shylini, R., Broad, C. E., Owoyemi, D., Martin, J., MacPhail, G., Iliodromiti, S., Riddell, A., Alexander, E., & Cutino-Moguel, T. (2022). Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Placental Infection Is Associated With Massive Perivillous Fibrin Deposition at the Maternal-Fetal Interface: A Preliminary Study. Clinical Infectious Diseases, 75(1), E1176-E1179. https://doi.org/10.1093/cid/ciac173

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title = "Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Placental Infection Is Associated With Massive Perivillous Fibrin Deposition at the Maternal-Fetal Interface: A Preliminary Study",

abstract = "We observed an increased frequency of massive perivillous fibrin deposition (MPFD) during the second coronavirus disease 2019 (COVID-19) pandemic wave dominated by the Alpha variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). MPFD associated with 100% reverse transcription polymerase chain reaction (RT-PCR) positivity for SARS-CoV-2 and detection by immunohistochemistry. The Alpha variant was identified in all placentas with MPFD that could be sequenced.",

keywords = "2, CoV, SARS, fibrin deposition, placenta",

author = "Esin Kotiloglu-Karaa and Beatrix Kele and Raghavendran Kulasegaran-Shylini and Broad, {Claire E.} and Dola Owoyemi and Joanne Martin and Graham MacPhail and Stamatina Iliodromiti and Anna Riddell and Eliza Alexander and Teresa Cutino-Moguel",

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language = "English",

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Kotiloglu-Karaa, E, Kele, B, Kulasegaran-Shylini, R, Broad, CE, Owoyemi, D, Martin, J, MacPhail, G, Iliodromiti, S, Riddell, A, Alexander, E & Cutino-Moguel, T 2022, 'Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Placental Infection Is Associated With Massive Perivillous Fibrin Deposition at the Maternal-Fetal Interface: A Preliminary Study', Clinical Infectious Diseases, vol. 75, no. 1, pp. E1176-E1179. https://doi.org/10.1093/cid/ciac173

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Placental Infection Is Associated With Massive Perivillous Fibrin Deposition at the Maternal-Fetal Interface: A Preliminary Study. / Kotiloglu-Karaa, Esin; Kele, Beatrix; Kulasegaran-Shylini, Raghavendran et al.
In: Clinical Infectious Diseases, Vol. 75, No. 1, 01.07.2022, p. E1176-E1179.

Research output: Contribution to journal › Article › peer-review

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T1 - Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Placental Infection Is Associated With Massive Perivillous Fibrin Deposition at the Maternal-Fetal Interface

T2 - A Preliminary Study

AU - Kotiloglu-Karaa, Esin

AU - Kele, Beatrix

AU - Kulasegaran-Shylini, Raghavendran

AU - Broad, Claire E.

AU - Owoyemi, Dola

AU - Martin, Joanne

AU - MacPhail, Graham

AU - Iliodromiti, Stamatina

AU - Riddell, Anna

AU - Alexander, Eliza

AU - Cutino-Moguel, Teresa

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KW - 2

KW - CoV

KW - SARS

KW - fibrin deposition

KW - placenta

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Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Placental Infection Is Associated With Massive Perivillous Fibrin Deposition at the Maternal-Fetal Interface: A Preliminary Study

Abstract

Bibliographical note

Keywords

UN SDGs

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