Serum Beta-D-Glucan in the Diagnosis of Invasive Fungal Disease in Neonates, Children and Adolescents: A Critical Analysis of Current Data

Laura Ferreras-Antolin; Andrew Borman; Antonia Diederichs; Adilia Warris; Thomas Lehrnbecher

doi:10.3390/jof8121262

Serum Beta-D-Glucan in the Diagnosis of Invasive Fungal Disease in Neonates, Children and Adolescents: A Critical Analysis of Current Data

Laura Ferreras-Antolin^*, Andrew Borman, Antonia Diederichs, Adilia Warris, Thomas Lehrnbecher

^*Corresponding author for this work

Bristol Mycology Reference Laboratory General

Research output: Contribution to journal › Review article › peer-review

13 Citations (Scopus)

Abstract

β-D-glucan (BDG) is a cell wall component of many pathogenic fungi. The detection of BDG as an assay is clinically broadly used as a diagnostic tool. However, the current data on BDG in paediatrics are limited, prompting specific considerations about when BDG can be used in neonates and children. We aimed to analyse the available data for the use of serum BDG in neonates and immunocompromised children and adolescents; as well as to understand the extent and characteristics of the use of BDG in children in Europe.

Original language	English
Article number	1262
Journal	Journal of Fungi
Volume	8
Issue number	12
DOIs	https://doi.org/10.3390/jof8121262
Publication status	Published - Dec 2022

Bibliographical note

Publisher Copyright:
© 2022 by the authors.

Keywords

fungal diagnostics
invasive fungal infections in children
neonatal invasive candidiasis
β-D-glucan

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10.3390/jof8121262

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title = "Serum Beta-D-Glucan in the Diagnosis of Invasive Fungal Disease in Neonates, Children and Adolescents: A Critical Analysis of Current Data",

abstract = "β-D-glucan (BDG) is a cell wall component of many pathogenic fungi. The detection of BDG as an assay is clinically broadly used as a diagnostic tool. However, the current data on BDG in paediatrics are limited, prompting specific considerations about when BDG can be used in neonates and children. We aimed to analyse the available data for the use of serum BDG in neonates and immunocompromised children and adolescents; as well as to understand the extent and characteristics of the use of BDG in children in Europe.",

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author = "Laura Ferreras-Antolin and Andrew Borman and Antonia Diederichs and Adilia Warris and Thomas Lehrnbecher",

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T1 - Serum Beta-D-Glucan in the Diagnosis of Invasive Fungal Disease in Neonates, Children and Adolescents

T2 - A Critical Analysis of Current Data

AU - Ferreras-Antolin, Laura

AU - Borman, Andrew

AU - Diederichs, Antonia

AU - Warris, Adilia

AU - Lehrnbecher, Thomas

PY - 2022/12

Y1 - 2022/12

N2 - β-D-glucan (BDG) is a cell wall component of many pathogenic fungi. The detection of BDG as an assay is clinically broadly used as a diagnostic tool. However, the current data on BDG in paediatrics are limited, prompting specific considerations about when BDG can be used in neonates and children. We aimed to analyse the available data for the use of serum BDG in neonates and immunocompromised children and adolescents; as well as to understand the extent and characteristics of the use of BDG in children in Europe.

AB - β-D-glucan (BDG) is a cell wall component of many pathogenic fungi. The detection of BDG as an assay is clinically broadly used as a diagnostic tool. However, the current data on BDG in paediatrics are limited, prompting specific considerations about when BDG can be used in neonates and children. We aimed to analyse the available data for the use of serum BDG in neonates and immunocompromised children and adolescents; as well as to understand the extent and characteristics of the use of BDG in children in Europe.

KW - fungal diagnostics

KW - invasive fungal infections in children

KW - neonatal invasive candidiasis

KW - β-D-glucan

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U2 - 10.3390/jof8121262

DO - 10.3390/jof8121262

M3 - Review article

AN - SCOPUS:85144694235

SN - 2309-608X

VL - 8

JO - Journal of Fungi

JF - Journal of Fungi

IS - 12

M1 - 1262

ER -

Serum Beta-D-Glucan in the Diagnosis of Invasive Fungal Disease in Neonates, Children and Adolescents: A Critical Analysis of Current Data

Abstract

Bibliographical note

Keywords

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