Serotype dynamics of invasive pneumococcal disease post-PCV7 and pre-PCV13 introduction in North East England

K. E. Chapman*, D. Wilson, Russell Gorton

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    17 Citations (Scopus)

    Abstract

    The 7-valent pneumococcal conjugate vaccine (PCV7) has been included in the routine childhood immunization programme in the UK since September 2006. A population-based study of serotypes causing invasive pneumococcal disease (IPD) post-PCV7 in North East England was conducted using data from a regional enhanced IPD surveillance system. Overall, there was a 20% reduction [95% confidence interval (CI) 5-32] from 12·1 cases/100 000 population in 2006/2007 to 9·7 in 2009/2010. There was a fall in IPD caused by PCV7 serotypes in all age groups, with reductions of 90% (95% CI 61-99) in children aged <5 years, 50% (95% CI 4-75) in persons aged 5-64 years and 66% (95% CI 40-82) in adults aged

    Original languageEnglish
    Pages (from-to)344-352
    Number of pages9
    JournalEpidemiology and Infection
    Volume141
    Issue number2
    DOIs
    Publication statusPublished - Feb 2013

    Keywords

    • Invasive pneumococcal disease
    • Streptococcus pneumoniae (pneumococcus)
    • pneumococcal conjugate vaccine

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