Seroprevalence of diphtheria immunity among injured adults in Austria

Stefan Marlovits*, Roland Stocker, Androulla Efstratiou, Karen Broughton, Alexandra Kaider, Vilmos Vécsei, Gerhard Wiedermann, Herwig Kollaritsch

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

20 Citations (Scopus)

Abstract

Over a period of 1 year a seroepidemiological study was conducted at the outpatient clinic of a trauma department. Immunity to diphtheria was determined in serum samples from 558 injured patients (205 women and 353 men, age from 18 to 70). Diphtheria-antitoxin concentrations were measured with an enzyme immunoassay and a tissue culture toxin-neutralization assay. Sero-immunity was classified as susceptibility (<0.01 IU/ml), basic protection (0.01 - <0.1 IU/ml) and full protection (≥0.1 IU/ml) against the toxic manifestations of the disease. A total of 27.1% of the subjects were susceptible to diphtheria, 26.5% had basic protection, and 46.4% were fully protected. The median antitoxin concentration reached 0.08 IU/ml (0.0-0.29; quartiles Q25-Q75). A non linear trend toward decreasing immunity with increasing age was observed (P < 0.001) and females proved less protected than males (P = 0.006). The country of original immunization (Austria, Western European countries, Eastern European countries and Non European countries) had no influence on sero-immunity (P = 0.49). Multiple linear regression analysis revealed that age (P < 0.001) and gender (P = 0.004) had a significant independent influence on diphtheria immunity level, whereas the country of original immunization was not significant (P = 0.72).

Original languageEnglish
Pages (from-to)1061-1067
Number of pages7
JournalVaccine
Volume19
Issue number9-10
DOIs
Publication statusPublished - 8 Dec 2000

Bibliographical note

Funding Information:
This study was supported by the Medizinisch-wissenschaftlicher Fonds des Bürgermeisters der Bundeshauptstadt Wien (grant 1409) and the Hochschuljubiläumsstiftung der Stadt Wien (grant H-88/97). We are indebted to the staff of the Trauma Department of the Vienna University Hospital for their extraordinary efforts, and to C. Tomann, M. Honauer, and H. Donhauser for technical assistance.

Keywords

  • Adults
  • Austria
  • Diphtheria
  • Immunity
  • Trauma

Fingerprint

Dive into the research topics of 'Seroprevalence of diphtheria immunity among injured adults in Austria'. Together they form a unique fingerprint.

Cite this