Seroprevalence of diphtheria immunity among injured adults in Austria

Stefan Marlovits*, Roland Stocker, Androulla Efstratiou, Karen Broughton, Alexandra Kaider, Vilmos Vécsei, Gerhard Wiedermann, Herwig Kollaritsch

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

22 Citations (Scopus)


Over a period of 1 year a seroepidemiological study was conducted at the outpatient clinic of a trauma department. Immunity to diphtheria was determined in serum samples from 558 injured patients (205 women and 353 men, age from 18 to 70). Diphtheria-antitoxin concentrations were measured with an enzyme immunoassay and a tissue culture toxin-neutralization assay. Sero-immunity was classified as susceptibility (<0.01 IU/ml), basic protection (0.01 - <0.1 IU/ml) and full protection (≥0.1 IU/ml) against the toxic manifestations of the disease. A total of 27.1% of the subjects were susceptible to diphtheria, 26.5% had basic protection, and 46.4% were fully protected. The median antitoxin concentration reached 0.08 IU/ml (0.0-0.29; quartiles Q25-Q75). A non linear trend toward decreasing immunity with increasing age was observed (P < 0.001) and females proved less protected than males (P = 0.006). The country of original immunization (Austria, Western European countries, Eastern European countries and Non European countries) had no influence on sero-immunity (P = 0.49). Multiple linear regression analysis revealed that age (P < 0.001) and gender (P = 0.004) had a significant independent influence on diphtheria immunity level, whereas the country of original immunization was not significant (P = 0.72).

Original languageEnglish
Pages (from-to)1061-1067
Number of pages7
Issue number9-10
Publication statusPublished - 8 Dec 2000
Externally publishedYes

Bibliographical note

Funding Information:
This study was supported by the Medizinisch-wissenschaftlicher Fonds des Bürgermeisters der Bundeshauptstadt Wien (grant 1409) and the Hochschuljubiläumsstiftung der Stadt Wien (grant H-88/97). We are indebted to the staff of the Trauma Department of the Vienna University Hospital for their extraordinary efforts, and to C. Tomann, M. Honauer, and H. Donhauser for technical assistance.


  • Adults
  • Austria
  • Diphtheria
  • Immunity
  • Trauma


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