Seroprevalence of antibody to varicella zoster virus in England and Wales in children and young adults

Andrew J. Vyse*, N. J. Gay, L. M. Hesketh, P. Morgan-Capner, Elizbeth Miller

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    67 Citations (Scopus)

    Abstract

    This is the first large-scale study to investigate the seroprevalence of varicella zoster (VZV) in the general population of England and Wales. The study focused on those aged 1-20 years, that age group in whom most infections occur. Prevalence rose rapidly with age, with 53% of children showing evidence of prior infection by the age of 5 years and most young adults having experienced infection. In addition to using a fixed cut-off recommended by the manufacturer, a mixture modelling technique was also used to define the proportion of the population seropositive in each age group. This was shown to be a more accurate approach to categorizing data from an epidemiological perspective.

    Original languageEnglish
    Pages (from-to)1129-1134
    Number of pages6
    JournalEpidemiology and Infection
    Volume132
    Issue number6
    DOIs
    Publication statusPublished - Dec 2004

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