Serological Profiling of Group A Streptococcus Infections in Acute Rheumatic Fever

Natalie Lorenz; Timothy K.C. Ho; Reuben Mcgregor; Mark R. Davies; Deborah A. Williamson; Jason K. Gurney; Pierre R. Smeesters; Michael G. Baker; Nicole J. Moreland

doi:10.1093/cid/ciab180

Serological Profiling of Group A Streptococcus Infections in Acute Rheumatic Fever

Natalie Lorenz
, Timothy K.C. Ho
, Reuben Mcgregor
, Mark R. Davies
, Deborah A. Williamson
, Jason K. Gurney
, Pierre R. Smeesters
, Michael G. Baker
, Nicole J. Moreland^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

34 Citations (Scopus)

Abstract

Rheumatic fever is a serious post-infectious sequela of group A Streptococcus (GAS). Prior GAS exposures were mapped in sera using a large panel of M-type specific peptides. Rheumatic fever patients had serological evidence of significantly more GAS exposures than matched controls suggesting immune priming by repeat infections contributes to pathogenesis.

Original language	English
Pages (from-to)	2322-2325
Number of pages	4
Journal	Clinical Infectious Diseases
Volume	73
Issue number	12
DOIs	https://doi.org/10.1093/cid/ciab180
Publication status	Published - 15 Dec 2021
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2021 The Author(s) 2021. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

emm-cluster
emm-type
group A Streptococcus
immune priming
rheumatic fever

Access to Document

10.1093/cid/ciab180

Cite this

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abstract = "Rheumatic fever is a serious post-infectious sequela of group A Streptococcus (GAS). Prior GAS exposures were mapped in sera using a large panel of M-type specific peptides. Rheumatic fever patients had serological evidence of significantly more GAS exposures than matched controls suggesting immune priming by repeat infections contributes to pathogenesis.",

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AU - Ho, Timothy K.C.

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AU - Williamson, Deborah A.

AU - Gurney, Jason K.

AU - Smeesters, Pierre R.

AU - Baker, Michael G.

AU - Moreland, Nicole J.

PY - 2021/12/15

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N2 - Rheumatic fever is a serious post-infectious sequela of group A Streptococcus (GAS). Prior GAS exposures were mapped in sera using a large panel of M-type specific peptides. Rheumatic fever patients had serological evidence of significantly more GAS exposures than matched controls suggesting immune priming by repeat infections contributes to pathogenesis.

AB - Rheumatic fever is a serious post-infectious sequela of group A Streptococcus (GAS). Prior GAS exposures were mapped in sera using a large panel of M-type specific peptides. Rheumatic fever patients had serological evidence of significantly more GAS exposures than matched controls suggesting immune priming by repeat infections contributes to pathogenesis.

KW - emm-cluster

KW - emm-type

KW - group A Streptococcus

KW - immune priming

KW - rheumatic fever

UR - https://www.scopus.com/pages/publications/85111565774

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JO - Clinical Infectious Diseases

JF - Clinical Infectious Diseases

IS - 12

ER -

Serological Profiling of Group A Streptococcus Infections in Acute Rheumatic Fever

Abstract

Bibliographical note

UN SDGs

Keywords

Access to Document

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