Serological investigation of various forms of inflammatory periodontitis

R. Farida, P. D. Marsh, H. N. Newman, D. C. Rule, L. Ivanyi*

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    31 Citations (Scopus)

    Abstract

    Antibody levels towards sonicated whole cell extracts of selected oral Gram negative bacteria and Actinomyces viscosus were determined in sera from patients with various inflammatory forms of periodontal disease and from healthy control individuals. Antibody titres to two (non‐leukotoxin producing) strains of Actinobacillus actinomycetemcomitans were significantly elevated in patients with juvenile periodontitis. Adult patients with severe periodontitis had significantly lower IgG antibody titres to Veillonella parvula (p < 0.001) or A. actinomycetemco‐mitans strain NCTC 9710 (p < 0.01) and patients with mild periodontitis had decreased IgM antibody titres to A. actinomycetemcomitans strain NCTC 10979 (p < 0.05) when compared with the control subjects. Young adults with severe periodontitis showed marked individual differences in their humoral responses. Analysis of data revealed that only patients with a history of juvenile periodontitis had elevated IgG antibody titres to Bacteroides gingivalis (p < 0.001) and to V. parvula (p < 0.01). Hence the profiles of antibody levels to oral microorganisms identified patients who had previously manifested classical “localised” juvenile periodontitis.

    Original languageEnglish
    Pages (from-to)365-374
    Number of pages10
    JournalJournal of Periodontal Research
    Volume21
    Issue number4
    DOIs
    Publication statusPublished - Jul 1986

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