Serologic correlates of protection for evaluating the response to meningococcal vaccines

Paul Balmer, Raymond Borrow*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

52 Citations (Scopus)

Abstract

Meningococci cause serious disease worldwide and the organism remains the most common cause of bacterial meningitis in children and young adults. The only effective means of controlling disease is through vaccination. Although polysaccharide vaccines have been available for serogroup A, C, Y and W135 for many years, serogroup C polysaccharide-protein conjugate vaccines have only recently been licensed in many countries. Conjugate vaccines for combinations of serogroup A, C, Y and W135 are progressing through clinical trials and major efforts are being made to develop a safe and efficacious vaccine against serogroup B. To assess the quality of the immune response after vaccination, laboratory correlates of protection are needed. For serogroups A and C, serum bactericidal antibody is a well established predictor for protection but for serogroup B, other mechanisms besides serum bactericidal antibody may also be involved in conferring protection against disease. The serologic correlates of protection for evaluating the response to meningococcal vaccines are described in this review.

Original languageEnglish
Pages (from-to)77-87
Number of pages11
JournalExpert Review of Vaccines
Volume3
Issue number1
DOIs
Publication statusPublished - Feb 2004
Externally publishedYes

Keywords

  • Correlate of protection
  • Immunologic memory
  • Meningococcal conjugate
  • Serum bactericidal antibody
  • Vaccine

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