TY - JOUR
T1 - Seroepidemiologic study of pandemic (H1N1) 2009 during outbreak in boarding school, England
AU - Johnson, Sandra
AU - Ihekweazu, Chikwe
AU - Hardelid, Pia
AU - Raphaely, Nika
AU - Hoschler, Katja
AU - Bermingham, Alison
AU - Abid, Muhammad
AU - Pebody, Richard
AU - Bickler, Graham
AU - Watson, John
AU - O'Moore, Éamonn
PY - 2011/9
Y1 - 2011/9
N2 - We conducted a seroepidemiologic study during an outbreak of pandemic (H1N1) 2009 in a boarding school in England. Overall, 353 (17%) of students and staff completed a questionnaire and provided a serum sample. The attack rate was 40.5% and 34.1% for self-reported acute respiratory infection (ARI). Staff were less likely to be seropositive than students 13-15 years of age (staff 20-49 years, adjusted odds ratio [AOR] 0.30; >50 years AOR 0.20). Teachers were more likely to be seropositive than other staff (AOR 7.47, 95% confi dence interval [CI] 2.31-24.2). Of seropositive persons, 44.6% (95% CI 36.2%-53.3%) did not report ARI. Conversely, of 141 with ARI and 63 with infl uenza-like illness, 45.8% (95% CI 37.0%-54.0%) and 30.2% (95% CI 19.2%-43.0%) had negative test results, respectively. A weak association was found between seropositivity and a prophylactic dose of antiviral agents (AOR 0.55, 95% CI 0.30-0.99); prophylactic antiviral agents lowered the odds of ARI by 50%.
AB - We conducted a seroepidemiologic study during an outbreak of pandemic (H1N1) 2009 in a boarding school in England. Overall, 353 (17%) of students and staff completed a questionnaire and provided a serum sample. The attack rate was 40.5% and 34.1% for self-reported acute respiratory infection (ARI). Staff were less likely to be seropositive than students 13-15 years of age (staff 20-49 years, adjusted odds ratio [AOR] 0.30; >50 years AOR 0.20). Teachers were more likely to be seropositive than other staff (AOR 7.47, 95% confi dence interval [CI] 2.31-24.2). Of seropositive persons, 44.6% (95% CI 36.2%-53.3%) did not report ARI. Conversely, of 141 with ARI and 63 with infl uenza-like illness, 45.8% (95% CI 37.0%-54.0%) and 30.2% (95% CI 19.2%-43.0%) had negative test results, respectively. A weak association was found between seropositivity and a prophylactic dose of antiviral agents (AOR 0.55, 95% CI 0.30-0.99); prophylactic antiviral agents lowered the odds of ARI by 50%.
UR - https://www.scopus.com/pages/publications/80052168839
U2 - 10.3201/eid1709.100761
DO - 10.3201/eid1709.100761
M3 - Article
C2 - 21888793
AN - SCOPUS:80052168839
SN - 1080-6040
VL - 17
SP - 1670
EP - 1677
JO - Emerging Infectious Diseases
JF - Emerging Infectious Diseases
IS - 9
ER -
