Sensitivity of Human Papillomavirus (HPV) Lineage and Sublineage Variant Pseudoviruses to Neutralization by Nonavalent Vaccine Antibodies

Anna Godi, Troy J. Kemp, Ligia A. Pinto, Simon Beddows*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

Natural variants of human papillomavirus (HPV) are classified into lineages and sublineages based upon whole-genome sequence, but the impact of diversity on protein function is unclear. We investigated the susceptibility of 3-8 representative pseudovirus variants of HPV16, HPV18, HPV31, HPV33, HPV45, HPV52, and HPV58 to neutralization by nonavalent vaccine (Gardasil®9) sera. Many variants demonstrated significant differences in neutralization sensitivity from their consensus A/A1 variant but these were of a low magnitude. HPV52 D and HPV58 C variants exhibited >4-fold reduced sensitivities compared to their consensus A/A1 variant and should be considered distinct serotypes with respect to nonavalent vaccine-induced immunity.

Original languageEnglish
Pages (from-to)1940-1945
Number of pages6
JournalJournal of Infectious Diseases
Volume220
Issue number12
DOIs
Publication statusPublished - 6 Nov 2019

Bibliographical note

Funding Information:
Financial support. This work was supported by Public Health England; the National Cancer Institute, National Institutes of Health (contract number HHSN261200800001E); and by the Bill and Melinda Gates Foundation to develop and distribute qualified standardized reagents for human papillomavirus research as a service to be made available to the extramural research community.

Publisher Copyright:
© 2019 The Author(s) 2019. Published by Oxford University Press for the Infectious Diseases Society of America.

Keywords

  • antibody
  • human papillomavirus
  • lineage
  • neutralization
  • vaccine
  • variant

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