Sensitive detection of SARS-CoV-2-Specific antibodies in dried blood spot samples

Gabriella L. Morley; Stephen Taylor; Sian Jossi; Marisol Perez-Toledo; Sian E. Faustini; Edith Marcial-Juarez; Adrian M. Shields; Margaret Goodall; Joel D. Allen; Yasunori Watanabe; Maddy L. Newby; Max Crispin; Mark T. Drayson; Adam F. Cunningham; Alex G. Richter; Matthew K. O'Shea

doi:10.3201/EID2612.203309

Sensitive detection of SARS-CoV-2-Specific antibodies in dried blood spot samples

Gabriella L. Morley, Stephen Taylor, Sian Jossi, Marisol Perez-Toledo, Sian E. Faustini, Edith Marcial-Juarez, Adrian M. Shields, Margaret Goodall, Joel D. Allen, Yasunori Watanabe, Maddy L. Newby, Max Crispin, Mark T. Drayson, Adam F. Cunningham, Alex G. Richter, Matthew K. O'Shea^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

64 Citations (Scopus)

Abstract

Dried blood spot (DBS) samples can be used for the detection of severe acute respiratory syndrome coronavirus 2 spike antibodies. DBS sampling is comparable to matched serum samples with a relative 98.1% sensitivity and 100% specificity. Thus, DBS sampling offers an alternative for population-wide serologic testing in the coronavirus pandemic.

Original language	English
Pages (from-to)	2970-2973
Number of pages	4
Journal	Emerging Infectious Diseases
Volume	26
Issue number	12
DOIs	https://doi.org/10.3201/EID2612.203309
Publication status	Published - Dec 2020
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2020 Centers for Disease Control and Prevention (CDC). All rights reserved.

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10.3201/EID2612.203309

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Morley, G. L., Taylor, S., Jossi, S., Perez-Toledo, M., Faustini, S. E., Marcial-Juarez, E., Shields, A. M., Goodall, M., Allen, J. D., Watanabe, Y., Newby, M. L., Crispin, M., Drayson, M. T., Cunningham, A. F., Richter, A. G., & O'Shea, M. K. (2020). Sensitive detection of SARS-CoV-2-Specific antibodies in dried blood spot samples. Emerging Infectious Diseases, 26(12), 2970-2973. https://doi.org/10.3201/EID2612.203309

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title = "Sensitive detection of SARS-CoV-2-Specific antibodies in dried blood spot samples",

abstract = "Dried blood spot (DBS) samples can be used for the detection of severe acute respiratory syndrome coronavirus 2 spike antibodies. DBS sampling is comparable to matched serum samples with a relative 98.1% sensitivity and 100% specificity. Thus, DBS sampling offers an alternative for population-wide serologic testing in the coronavirus pandemic.",

author = "Morley, {Gabriella L.} and Stephen Taylor and Sian Jossi and Marisol Perez-Toledo and Faustini, {Sian E.} and Edith Marcial-Juarez and Shields, {Adrian M.} and Margaret Goodall and Allen, {Joel D.} and Yasunori Watanabe and Newby, {Maddy L.} and Max Crispin and Drayson, {Mark T.} and Cunningham, {Adam F.} and Richter, {Alex G.} and O'Shea, {Matthew K.}",

year = "2020",

month = dec,

doi = "10.3201/EID2612.203309",

language = "English",

volume = "26",

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Morley, GL, Taylor, S, Jossi, S, Perez-Toledo, M, Faustini, SE, Marcial-Juarez, E, Shields, AM, Goodall, M, Allen, JD, Watanabe, Y, Newby, ML, Crispin, M, Drayson, MT, Cunningham, AF, Richter, AG & O'Shea, MK 2020, 'Sensitive detection of SARS-CoV-2-Specific antibodies in dried blood spot samples', Emerging Infectious Diseases, vol. 26, no. 12, pp. 2970-2973. https://doi.org/10.3201/EID2612.203309

TY - JOUR

T1 - Sensitive detection of SARS-CoV-2-Specific antibodies in dried blood spot samples

AU - Morley, Gabriella L.

AU - Taylor, Stephen

AU - Jossi, Sian

AU - Perez-Toledo, Marisol

AU - Faustini, Sian E.

AU - Marcial-Juarez, Edith

AU - Shields, Adrian M.

AU - Goodall, Margaret

AU - Allen, Joel D.

AU - Watanabe, Yasunori

AU - Newby, Maddy L.

AU - Crispin, Max

AU - Drayson, Mark T.

AU - Cunningham, Adam F.

AU - Richter, Alex G.

AU - O'Shea, Matthew K.

PY - 2020/12

Y1 - 2020/12

N2 - Dried blood spot (DBS) samples can be used for the detection of severe acute respiratory syndrome coronavirus 2 spike antibodies. DBS sampling is comparable to matched serum samples with a relative 98.1% sensitivity and 100% specificity. Thus, DBS sampling offers an alternative for population-wide serologic testing in the coronavirus pandemic.

AB - Dried blood spot (DBS) samples can be used for the detection of severe acute respiratory syndrome coronavirus 2 spike antibodies. DBS sampling is comparable to matched serum samples with a relative 98.1% sensitivity and 100% specificity. Thus, DBS sampling offers an alternative for population-wide serologic testing in the coronavirus pandemic.

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SN - 1080-6040

VL - 26

SP - 2970

EP - 2973

JO - Emerging Infectious Diseases

JF - Emerging Infectious Diseases

IS - 12

ER -

Sensitive detection of SARS-CoV-2-Specific antibodies in dried blood spot samples

Abstract

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