Sedentary time and markers of inflammation in people with newly diagnosed type 2 diabetes

C. L. Falconer*, A. R. Cooper, J. P. Walhin, D. Thompson, A. S. Page, T. J. Peters, A. A. Montgomery, D. J. Sharp, C. M. Dayan, R. C. Andrews

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

46 Citations (Scopus)

Abstract

Background and aims: We investigated whether objectively measured sedentary time was associated with markers of inflammation in adults with newly diagnosed type 2 diabetes. Methods and results: We studied 285 adults (184 men, 101 women, mean age 59.0 ± 9.7) who had been recruited to the Early ACTivity in Diabetes (Early ACTID) randomised controlled trial. C-reactive protein (CRP), adiponectin, soluble intracellular adhesion molecule-1 (sICAM-1), interleukin-6 (IL-6), and accelerometer-determined sedentary time and moderate-vigorous physical activity (MVPA) were measured at baseline and after six-months. Linear regression analysis was used to investigate the independent cross-sectional and longitudinal associations of sedentary time with markers of inflammation.At baseline, associations between sedentary time and IL-6 were observed in men and women, an association that was attenuated following adjustment for waist circumference. After 6 months of follow-up, sedentary time was reduced by 0.4 ± 1.2 h per day in women, with the change in sedentary time predicting CRP at follow-up. Every hour decrease in sedentary time between baseline and six-months was associated with 24% (1, 48) lower CRP. No changes in sedentary time between baseline and 6 months were seen in men. Conclusions: Higher sedentary time is associated with IL-6 in men and women with type 2 diabetes, and reducing sedentary time is associated with improved levels of CRP in women. Interventions to reduce sedentary time may help to reduce inflammation in women with type 2 diabetes.

Original languageEnglish
Pages (from-to)956-962
Number of pages7
JournalNutrition, Metabolism and Cardiovascular Diseases
Volume24
Issue number9
DOIs
Publication statusPublished - 2014
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2014 Elsevier B.V.

Keywords

  • Breaks in sedentary time
  • Inflammation
  • Sedentary time
  • Type 2 diabetes

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