Secondary Attack Rate and Family Clustering of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection in Children of Healthcare Workers with Confirmed Coronavirus Disease 2019 (COVID-19)

Shamez N. Ladhani; Nick Andrews; Felicity Aiano; Frances Baawuah; Zahin Amin-Chowdhury; Kevin E. Brown; Gayatri Amirthalingam; Mary E. Ramsay; Thomas Waterfield; Chris Watson; Rebecca Moore; Kathryn Ferris; Claire Tonry; Alison P. Watt; Claire McGinn; Steven Foster; Jennifer Evans; Mark D. Lyttle; Shazaad Ahmad; Michael Corr; Lisa McFetridge; Hannah Mitchell; Julie Ann Maney; Sharon Christie

doi:10.1093/cid/ciaa1737

Secondary Attack Rate and Family Clustering of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection in Children of Healthcare Workers with Confirmed Coronavirus Disease 2019 (COVID-19)

Shamez N. Ladhani^*, Nick Andrews, Felicity Aiano, Frances Baawuah, Zahin Amin-Chowdhury, Kevin E. Brown, Gayatri Amirthalingam, Mary E. Ramsay, Thomas Waterfield, Chris Watson, Rebecca Moore, Kathryn Ferris, Claire Tonry, Alison P. Watt, Claire McGinn, Steven Foster, Jennifer Evans, Mark D. Lyttle, Shazaad Ahmad, Michael CorrLisa McFetridge, Hannah Mitchell, Julie Ann Maney, Sharon Christie

^*Corresponding author for this work

Manchester Lab

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

We measured serum SARS-CoV-2 antibodies in 215 children of healthcare workers to estimate secondary attack rates. Twenty-one families had a parent with confirmed COVID-19. There was strong evidence of family clustering (P<.001): 20/21 (95.2%) children were seropositive in 9 families and none of 23 children in 12 other families.

Original language	English
Pages (from-to)	E260-E263
Number of pages	4
Journal	Clinical Infectious Diseases
Volume	73
Issue number	1
Early online date	17 Nov 2020
DOIs	https://doi.org/10.1093/cid/ciaa1737
Publication status	Published - 1 Jul 2021

Bibliographical note

Funding information: The authors: No reported conflicts of interest. All authors have submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Conflicts that the editors consider relevant to the content of the manuscript have been disclosed.

Open Access: No Open Access licence.

Publisher Copyright: © 2020 The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved.

Citation: Shamez N Ladhani, Nick Andrews, Felicity Aiano, Frances Baawuah, Zahin Amin-Chowdhury, Kevin E Brown, Gayatri Amirthalingam, Mary E Ramsay, Thomas Waterfield, RAPID-19 Investigation Team, Secondary Attack Rate and Family Clustering of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection in Children of Healthcare Workers With Confirmed Coronavirus Disease 2019 (COVID-19), Clinical Infectious Diseases, Volume 73, Issue 1, 1 July 2021, Pages e260–e263.

DOI: https://doi.org/10.1093/cid/ciaa1737

Keywords

COVID-19
children
healthcare workers
secondary attack rates

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1093/cid/ciaa1737

Cite this

Ladhani, S. N., Andrews, N., Aiano, F., Baawuah, F., Amin-Chowdhury, Z., Brown, K. E., Amirthalingam, G., Ramsay, M. E., Waterfield, T., Watson, C., Moore, R., Ferris, K., Tonry, C., Watt, A. P., McGinn, C., Foster, S., Evans, J., Lyttle, M. D., Ahmad, S., ... Christie, S. (2021). Secondary Attack Rate and Family Clustering of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection in Children of Healthcare Workers with Confirmed Coronavirus Disease 2019 (COVID-19). Clinical Infectious Diseases, 73(1), E260-E263. https://doi.org/10.1093/cid/ciaa1737

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abstract = "We measured serum SARS-CoV-2 antibodies in 215 children of healthcare workers to estimate secondary attack rates. Twenty-one families had a parent with confirmed COVID-19. There was strong evidence of family clustering (P<.001): 20/21 (95.2%) children were seropositive in 9 families and none of 23 children in 12 other families.",

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author = "Ladhani, {Shamez N.} and Nick Andrews and Felicity Aiano and Frances Baawuah and Zahin Amin-Chowdhury and Brown, {Kevin E.} and Gayatri Amirthalingam and Ramsay, {Mary E.} and Thomas Waterfield and Chris Watson and Rebecca Moore and Kathryn Ferris and Claire Tonry and Watt, {Alison P.} and Claire McGinn and Steven Foster and Jennifer Evans and Lyttle, {Mark D.} and Shazaad Ahmad and Michael Corr and Lisa McFetridge and Hannah Mitchell and Maney, {Julie Ann} and Sharon Christie",

note = "Funding information: The authors: No reported conflicts of interest. All authors have submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Conflicts that the editors consider relevant to the content of the manuscript have been disclosed. Open Access: No Open Access licence. Publisher Copyright: {\textcopyright} 2020 The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. Citation: Shamez N Ladhani, Nick Andrews, Felicity Aiano, Frances Baawuah, Zahin Amin-Chowdhury, Kevin E Brown, Gayatri Amirthalingam, Mary E Ramsay, Thomas Waterfield, RAPID-19 Investigation Team, Secondary Attack Rate and Family Clustering of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection in Children of Healthcare Workers With Confirmed Coronavirus Disease 2019 (COVID-19), Clinical Infectious Diseases, Volume 73, Issue 1, 1 July 2021, Pages e260–e263. DOI: https://doi.org/10.1093/cid/ciaa1737 ",

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Ladhani, SN , Andrews, N, Aiano, F, Baawuah, F, Amin-Chowdhury, Z , Brown, KE , Amirthalingam, G , Ramsay, ME, Waterfield, T, Watson, C, Moore, R, Ferris, K, Tonry, C, Watt, AP, McGinn, C, Foster, S, Evans, J, Lyttle, MD, Ahmad, S, Corr, M, McFetridge, L, Mitchell, H, Maney, JA & Christie, S 2021, 'Secondary Attack Rate and Family Clustering of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection in Children of Healthcare Workers with Confirmed Coronavirus Disease 2019 (COVID-19)', Clinical Infectious Diseases, vol. 73, no. 1, pp. E260-E263. https://doi.org/10.1093/cid/ciaa1737

Secondary Attack Rate and Family Clustering of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection in Children of Healthcare Workers with Confirmed Coronavirus Disease 2019 (COVID-19). / Ladhani, Shamez N.; Andrews, Nick; Aiano, Felicity et al.
In: Clinical Infectious Diseases, Vol. 73, No. 1, 01.07.2021, p. E260-E263.

Research output: Contribution to journal › Article › peer-review

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AU - Andrews, Nick

AU - Aiano, Felicity

AU - Baawuah, Frances

AU - Amin-Chowdhury, Zahin

AU - Brown, Kevin E.

AU - Amirthalingam, Gayatri

AU - Ramsay, Mary E.

AU - Waterfield, Thomas

AU - Watson, Chris

AU - Moore, Rebecca

AU - Ferris, Kathryn

AU - Tonry, Claire

AU - Watt, Alison P.

AU - McGinn, Claire

AU - Foster, Steven

AU - Evans, Jennifer

AU - Lyttle, Mark D.

AU - Ahmad, Shazaad

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AU - Mitchell, Hannah

AU - Maney, Julie Ann

AU - Christie, Sharon

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Ladhani SN , Andrews N, Aiano F, Baawuah F, Amin-Chowdhury Z , Brown KE et al. Secondary Attack Rate and Family Clustering of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection in Children of Healthcare Workers with Confirmed Coronavirus Disease 2019 (COVID-19). Clinical Infectious Diseases. 2021 Jul 1;73(1):E260-E263. Epub 2020 Nov 17. doi: 10.1093/cid/ciaa1737

Secondary Attack Rate and Family Clustering of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection in Children of Healthcare Workers with Confirmed Coronavirus Disease 2019 (COVID-19)

Abstract

Bibliographical note

Keywords

UN SDGs

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