Seasonality and immunity to laboratory-confirmed seasonal coronaviruses (HCoV-NL63, HCoV-OC43, and HCoV-229E): results from the Flu Watch cohort study [version 1; peer review: 2 approved with reservations]

Robert W. Aldridge; Dan Lewer; Sarah Beale; Anne M. Johnson; Maria Zambon; Andrew C. Hayward; Ellen B. Fragaszy; Flu Watch Group

doi:10.12688/WELLCOMEOPENRES.15812.1

Seasonality and immunity to laboratory-confirmed seasonal coronaviruses (HCoV-NL63, HCoV-OC43, and HCoV-229E): results from the Flu Watch cohort study [version 1; peer review: 2 approved with reservations]

Robert W. Aldridge, Dan Lewer, Sarah Beale, Anne M. Johnson, Maria Zambon, Andrew C. Hayward^*, Ellen B. Fragaszy, Flu Watch Group

^*Corresponding author for this work

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Abstract

Background: There is currently a pandemic caused by the novel coronavirus SARS-CoV-2. The intensity and duration of this first wave in the UK may be dependent on whether SARS-CoV-2 transmits more effectively in the winter than the summer and the UK Government response is partially built upon the assumption that those infected will develop immunity to reinfection in the short term. In this paper we examine evidence for seasonality and immunity to laboratoryconfirmed seasonal coronavirus (HCoV) from a prospective cohort study in England. Methods: In this analysis of the Flu Watch cohort, we examine seasonal trends for PCR-confirmed coronavirus infections (HCoVNL63, HCoV-OC43, and HCoV-229E) in all participants during winter seasons (2006-2007, 2007-2008, 2008-2009) and during the first wave of the 2009 H1N1 influenza pandemic (May-Sep 2009). We also included data from the pandemic and ‘post-pandemic’ winter seasons (2009-2010 and 2010-2011) to identify individuals with two confirmed HCoV infections and examine evidence for immunity against homologous reinfection. Results: We tested 1,104 swabs taken during respiratory illness and detected HCoV in 199 during the first four seasons.

Original language	English
Pages (from-to)	1-17
Number of pages	17
Journal	Wellcome Open Research
Volume	5
DOIs	https://doi.org/10.12688/WELLCOMEOPENRES.15812.1
Publication status	Published - 2020

Bibliographical note

Publisher Copyright:
© 2020. Aldridge RW et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Keywords

HCoV-229E
HCoV-NL63
HCoV-OC43
SARS-CoV-2
epidemiology
pandemic
public health

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Aldridge, R. W., Lewer, D., Beale, S., Johnson, A. M., Zambon, M., Hayward, A. C., Fragaszy, E. B., & Group, F. W. (2020). Seasonality and immunity to laboratory-confirmed seasonal coronaviruses (HCoV-NL63, HCoV-OC43, and HCoV-229E): results from the Flu Watch cohort study [version 1; peer review: 2 approved with reservations]. Wellcome Open Research, 5, 1-17. https://doi.org/10.12688/WELLCOMEOPENRES.15812.1

@article{5378e6e1ebc747cf8a3320a9b8efaaf6,

title = "Seasonality and immunity to laboratory-confirmed seasonal coronaviruses (HCoV-NL63, HCoV-OC43, and HCoV-229E): results from the Flu Watch cohort study [version 1; peer review: 2 approved with reservations]",

abstract = "Background: There is currently a pandemic caused by the novel coronavirus SARS-CoV-2. The intensity and duration of this first wave in the UK may be dependent on whether SARS-CoV-2 transmits more effectively in the winter than the summer and the UK Government response is partially built upon the assumption that those infected will develop immunity to reinfection in the short term. In this paper we examine evidence for seasonality and immunity to laboratoryconfirmed seasonal coronavirus (HCoV) from a prospective cohort study in England. Methods: In this analysis of the Flu Watch cohort, we examine seasonal trends for PCR-confirmed coronavirus infections (HCoVNL63, HCoV-OC43, and HCoV-229E) in all participants during winter seasons (2006-2007, 2007-2008, 2008-2009) and during the first wave of the 2009 H1N1 influenza pandemic (May-Sep 2009). We also included data from the pandemic and {\textquoteleft}post-pandemic{\textquoteright} winter seasons (2009-2010 and 2010-2011) to identify individuals with two confirmed HCoV infections and examine evidence for immunity against homologous reinfection. Results: We tested 1,104 swabs taken during respiratory illness and detected HCoV in 199 during the first four seasons.",

keywords = "HCoV-229E, HCoV-NL63, HCoV-OC43, SARS-CoV-2, epidemiology, pandemic, public health",

author = "Aldridge, \{Robert W.\} and Dan Lewer and Sarah Beale and Johnson, \{Anne M.\} and Maria Zambon and Hayward, \{Andrew C.\} and Fragaszy, \{Ellen B.\} and Group, \{Flu Watch\}",

note = "Publisher Copyright: {\textcopyright} 2020. Aldridge RW et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.",

year = "2020",

doi = "10.12688/WELLCOMEOPENRES.15812.1",

language = "English",

volume = "5",

pages = "1--17",

journal = "Wellcome Open Research",

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publisher = "F1000 Research Ltd",

}

Aldridge, RW, Lewer, D, Beale, S, Johnson, AM, Zambon, M, Hayward, AC, Fragaszy, EB & Group, FW 2020, 'Seasonality and immunity to laboratory-confirmed seasonal coronaviruses (HCoV-NL63, HCoV-OC43, and HCoV-229E): results from the Flu Watch cohort study [version 1; peer review: 2 approved with reservations]', Wellcome Open Research, vol. 5, pp. 1-17. https://doi.org/10.12688/WELLCOMEOPENRES.15812.1

Seasonality and immunity to laboratory-confirmed seasonal coronaviruses (HCoV-NL63, HCoV-OC43, and HCoV-229E): results from the Flu Watch cohort study [version 1; peer review: 2 approved with reservations]. / Aldridge, Robert W.; Lewer, Dan; Beale, Sarah et al.
In: Wellcome Open Research, Vol. 5, 2020, p. 1-17.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Seasonality and immunity to laboratory-confirmed seasonal coronaviruses (HCoV-NL63, HCoV-OC43, and HCoV-229E)

T2 - results from the Flu Watch cohort study [version 1; peer review: 2 approved with reservations]

AU - Aldridge, Robert W.

AU - Lewer, Dan

AU - Beale, Sarah

AU - Johnson, Anne M.

AU - Zambon, Maria

AU - Hayward, Andrew C.

AU - Fragaszy, Ellen B.

AU - Group, Flu Watch

N1 - Publisher Copyright: © 2020. Aldridge RW et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

PY - 2020

Y1 - 2020

N2 - Background: There is currently a pandemic caused by the novel coronavirus SARS-CoV-2. The intensity and duration of this first wave in the UK may be dependent on whether SARS-CoV-2 transmits more effectively in the winter than the summer and the UK Government response is partially built upon the assumption that those infected will develop immunity to reinfection in the short term. In this paper we examine evidence for seasonality and immunity to laboratoryconfirmed seasonal coronavirus (HCoV) from a prospective cohort study in England. Methods: In this analysis of the Flu Watch cohort, we examine seasonal trends for PCR-confirmed coronavirus infections (HCoVNL63, HCoV-OC43, and HCoV-229E) in all participants during winter seasons (2006-2007, 2007-2008, 2008-2009) and during the first wave of the 2009 H1N1 influenza pandemic (May-Sep 2009). We also included data from the pandemic and ‘post-pandemic’ winter seasons (2009-2010 and 2010-2011) to identify individuals with two confirmed HCoV infections and examine evidence for immunity against homologous reinfection. Results: We tested 1,104 swabs taken during respiratory illness and detected HCoV in 199 during the first four seasons.

AB - Background: There is currently a pandemic caused by the novel coronavirus SARS-CoV-2. The intensity and duration of this first wave in the UK may be dependent on whether SARS-CoV-2 transmits more effectively in the winter than the summer and the UK Government response is partially built upon the assumption that those infected will develop immunity to reinfection in the short term. In this paper we examine evidence for seasonality and immunity to laboratoryconfirmed seasonal coronavirus (HCoV) from a prospective cohort study in England. Methods: In this analysis of the Flu Watch cohort, we examine seasonal trends for PCR-confirmed coronavirus infections (HCoVNL63, HCoV-OC43, and HCoV-229E) in all participants during winter seasons (2006-2007, 2007-2008, 2008-2009) and during the first wave of the 2009 H1N1 influenza pandemic (May-Sep 2009). We also included data from the pandemic and ‘post-pandemic’ winter seasons (2009-2010 and 2010-2011) to identify individuals with two confirmed HCoV infections and examine evidence for immunity against homologous reinfection. Results: We tested 1,104 swabs taken during respiratory illness and detected HCoV in 199 during the first four seasons.

KW - HCoV-229E

KW - HCoV-NL63

KW - HCoV-OC43

KW - SARS-CoV-2

KW - epidemiology

KW - pandemic

KW - public health

UR - http://www.scopus.com/inward/record.url?scp=85094685428&partnerID=8YFLogxK

U2 - 10.12688/WELLCOMEOPENRES.15812.1

DO - 10.12688/WELLCOMEOPENRES.15812.1

M3 - Article

AN - SCOPUS:85094685428

SN - 2398-502X

VL - 5

SP - 1

EP - 17

JO - Wellcome Open Research

JF - Wellcome Open Research

ER -

Seasonality and immunity to laboratory-confirmed seasonal coronaviruses (HCoV-NL63, HCoV-OC43, and HCoV-229E): results from the Flu Watch cohort study [version 1; peer review: 2 approved with reservations]

Abstract

Bibliographical note

Keywords

UN SDGs

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