Screening for Corynebacterium diphtheriae and Corynebacterium ulcerans in patients with upper respiratory tract infections 2007-2008: A multicentre European study

K. S. Wagner, Joanne White, Shona Neal, Natasha Crowcroft, N. Kuprevičiene, R. Paberza, I. Lucenko, U. Jõks, E. Akbaş, H. Alexandrou-Athanassoulis, A. Detcheva, J. Vuopio, C. von Hunolstein, P. G. Murphy, Nicholas Andrews, Androulla Efstratiou*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

46 Citations (Scopus)


Diphtheria is now rare in most European countries but, when cases do arise, the case fatality rate is high (5-10%). Because few countries continue to routinely screen for the causative organisms of diphtheria, the extent to which they are circulating amongst different European populations is largely unknown. During 2007-2008, ten European countries each screened between 968 and 8551 throat swabs from patients with upper respiratory tract infections. Six toxigenic strains of Corynebacterium diphtheriae were identified: two from symptomatic patients in Latvia (the country with the highest reported incidence of diphtheria in the European Union) and four from Lithuania (two cases, two carriers); the last reported case of diphtheria in Lithuania was in 2002. Carriage rates of non-toxigenic organisms ranged from 0 (Bulgaria, Finland, Greece, Ireland, Italy) to 4.0 per 1000 (95% CI 2.0-7.1) in Turkey. A total of 28 non-toxigenic strains were identified during the study (26 C. diphtheriae, one Corynebacterium ulcerans, one Corynebacterium pseudotuberculosis). The non-toxigenic C. ulcerans strain was isolated from the UK, the country with the highest reported incidence of cases due to C. ulcerans. Of the eleven ribotypes detected, Cluj was seen most frequently in the non-toxigenic isolates and, amongst toxigenic isolates, the major epidemic clone, Sankt-Petersburg, is still in circulation. Isolation of toxigenic C. diphtheriae and non-toxigenic C. diphtheriae and C. ulcerans in highly-vaccinated populations highlights the need to maintain microbiological surveillance, laboratory expertise and an awareness of these organisms amongst public health specialists, microbiologists and clinicians.

Original languageEnglish
Pages (from-to)519-525
Number of pages7
JournalClinical Microbiology and Infection
Issue number4
Publication statusPublished - Apr 2011

Bibliographical note

Funding Information:
Financial support: the UK, Finland, Latvia, Lithuania, Greece, Estonia, Italy, Turkey and Bulgaria received funding for consumables from DIPNET, which is supported by the European Commission DG SANCO agreement number 2005210. The UK is the lead DIPNET partner; in total, there are 25 beneficiary countries and 21 collaborating countries. The study in Ireland was supported by funds from the Health Service Executive, Health Protection Surveillance Centre. All authors declare that there are no conflicts of interest.


  • Corynebacteria
  • Diphtheria
  • Screening


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