Salmonella identified in pigs in kenya and malawi reveals the potential for zoonotic transmission in emerging pork markets

Catherine N. Wilson; Caisey V. Pulford; James Akoko; Blanca Perez Sepulveda; Alexander V. Predeus; Jessica Bevington; Patricia Duncan; Neil Hall; Paul Wigley; Nicholas Feasey; Gina Pinchbeck; Jay C.D. Hinton; Melita A. Gordon; Eric M. Fèvre

doi:10.1371/journal.pntd.0008796

Salmonella identified in pigs in kenya and malawi reveals the potential for zoonotic transmission in emerging pork markets

Catherine N. Wilson^*, Caisey V. Pulford, James Akoko, Blanca Perez Sepulveda, Alexander V. Predeus, Jessica Bevington, Patricia Duncan, Neil Hall, Paul Wigley, Nicholas Feasey, Gina Pinchbeck, Jay C.D. Hinton, Melita A. Gordon, Eric M. Fèvre^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

Abstract

Salmonella is a major cause of foodborne disease globally. Pigs can carry and shed non-typhoidal Salmonella (NTS) asymptomatically, representing a significant reservoir for these pathogens. To investigate Salmonella carriage by African domestic pigs, faecal and mesen-teric lymph node samples were taken at slaughter in Nairobi, Busia (Kenya) and Chikwawa (Malawi) between October 2016 and May 2017. Selective culture, antisera testing and whole genome sequencing were performed on samples from 647 pigs; the prevalence of NTS carriage was 12.7% in Busia, 9.1% in Nairobi and 24.6% in Chikwawa. Two isolates of S. Typhimurium ST313 were isolated, but were more closely related to ST313 isolates associated with gastroenteritis in the UK than bloodstream infection in Africa. The discovery of porcine NTS carriage in Kenya and Malawi reveals potential for zoonotic transmission of diarrhoeal strains to humans in these countries, but not for transmission of clades specifi-cally associated with invasive NTS disease in Africa.

Original language	English
Article number	e0008796
Pages (from-to)	1-16
Number of pages	16
Journal	PLoS Neglected Tropical Diseases
Volume	14
Issue number	11
DOIs	https://doi.org/10.1371/journal.pntd.0008796
Publication status	Published - Nov 2020
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2020 Wilson et al.

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Wilson, C. N., Pulford, C. V., Akoko, J., Sepulveda, B. P., Predeus, A. V., Bevington, J., Duncan, P., Hall, N., Wigley, P., Feasey, N., Pinchbeck, G., Hinton, J. C. D., Gordon, M. A., & Fèvre, E. M. (2020). Salmonella identified in pigs in kenya and malawi reveals the potential for zoonotic transmission in emerging pork markets. PLoS Neglected Tropical Diseases, 14(11), 1-16. Article e0008796. https://doi.org/10.1371/journal.pntd.0008796

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abstract = "Salmonella is a major cause of foodborne disease globally. Pigs can carry and shed non-typhoidal Salmonella (NTS) asymptomatically, representing a significant reservoir for these pathogens. To investigate Salmonella carriage by African domestic pigs, faecal and mesen-teric lymph node samples were taken at slaughter in Nairobi, Busia (Kenya) and Chikwawa (Malawi) between October 2016 and May 2017. Selective culture, antisera testing and whole genome sequencing were performed on samples from 647 pigs; the prevalence of NTS carriage was 12.7% in Busia, 9.1% in Nairobi and 24.6% in Chikwawa. Two isolates of S. Typhimurium ST313 were isolated, but were more closely related to ST313 isolates associated with gastroenteritis in the UK than bloodstream infection in Africa. The discovery of porcine NTS carriage in Kenya and Malawi reveals potential for zoonotic transmission of diarrhoeal strains to humans in these countries, but not for transmission of clades specifi-cally associated with invasive NTS disease in Africa.",

author = "Wilson, {Catherine N.} and Pulford, {Caisey V.} and James Akoko and Sepulveda, {Blanca Perez} and Predeus, {Alexander V.} and Jessica Bevington and Patricia Duncan and Neil Hall and Paul Wigley and Nicholas Feasey and Gina Pinchbeck and Hinton, {Jay C.D.} and Gordon, {Melita A.} and F{\`e}vre, {Eric M.}",

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Wilson, CN, Pulford, CV, Akoko, J, Sepulveda, BP, Predeus, AV, Bevington, J, Duncan, P, Hall, N, Wigley, P, Feasey, N, Pinchbeck, G, Hinton, JCD, Gordon, MA & Fèvre, EM 2020, 'Salmonella identified in pigs in kenya and malawi reveals the potential for zoonotic transmission in emerging pork markets', PLoS Neglected Tropical Diseases, vol. 14, no. 11, e0008796, pp. 1-16. https://doi.org/10.1371/journal.pntd.0008796

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Salmonella identified in pigs in kenya and malawi reveals the potential for zoonotic transmission in emerging pork markets

Abstract

Bibliographical note

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