Routinely vaccinating adolescents against meningococcus: Targeting transmission & disease

Volker Vetter; Roger Baxter; Gülhan Denizer; Marco A.P. Sáfadi; Sven Arne Silfverdal; Andrew Vyse; Raymond Borrow

doi:10.1586/14760584.2016.1130628

Routinely vaccinating adolescents against meningococcus: Targeting transmission & disease

Volker Vetter, Roger Baxter, Gülhan Denizer^*, Marco A.P. Sáfadi, Sven Arne Silfverdal, Andrew Vyse, Raymond Borrow

^*Corresponding author for this work

Manchester Meningococcal Reference Unit General

Research output: Contribution to journal › Review article › peer-review

59 Citations (Scopus)

Abstract

Adolescents have the highest rates of meningococcal carriage and transmission. Interrupting the adolescent habitat in order to reduce carriage and transmission within adolescents and to other age groups could help to control meningococcal disease at a population level. Compared to immunization strategies restricted to young children, a strategy focused on adolescents may have more profound and long-lasting indirect impacts, and may be more cost effective. Despite challenges in reaching this age-group, experience with other vaccines show that high vaccine coverage of adolescents is attainable.

Original language	English
Pages (from-to)	641-658
Number of pages	18
Journal	Expert Review of Vaccines
Volume	15
Issue number	5
DOIs	https://doi.org/10.1586/14760584.2016.1130628
Publication status	Published - 3 May 2016

Bibliographical note

Publisher Copyright:
© 2016 The Author(s). Published by Taylor & Francis.

Keywords

Neisseria meningitides
adolescent
carriage
cost-effectiveness
epidemiology
herd protection
transmission
vaccine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1586/14760584.2016.1130628

Cite this

@article{dc83084ebe564422afec1b8881c71ce0,

title = "Routinely vaccinating adolescents against meningococcus: Targeting transmission & disease",

abstract = "Adolescents have the highest rates of meningococcal carriage and transmission. Interrupting the adolescent habitat in order to reduce carriage and transmission within adolescents and to other age groups could help to control meningococcal disease at a population level. Compared to immunization strategies restricted to young children, a strategy focused on adolescents may have more profound and long-lasting indirect impacts, and may be more cost effective. Despite challenges in reaching this age-group, experience with other vaccines show that high vaccine coverage of adolescents is attainable.",

keywords = "Neisseria meningitides, adolescent, carriage, cost-effectiveness, epidemiology, herd protection, transmission, vaccine",

author = "Volker Vetter and Roger Baxter and G{\"u}lhan Denizer and S{\'a}fadi, {Marco A.P.} and Silfverdal, {Sven Arne} and Andrew Vyse and Raymond Borrow",

note = "Publisher Copyright: {\textcopyright} 2016 The Author(s). Published by Taylor & Francis.",

year = "2016",

month = may,

day = "3",

doi = "10.1586/14760584.2016.1130628",

language = "English",

volume = "15",

pages = "641--658",

journal = "Expert Review of Vaccines",

issn = "1476-0584",

publisher = "Taylor and Francis Ltd.",

number = "5",

}

TY - JOUR

T1 - Routinely vaccinating adolescents against meningococcus

T2 - Targeting transmission & disease

AU - Vetter, Volker

AU - Baxter, Roger

AU - Denizer, Gülhan

AU - Sáfadi, Marco A.P.

AU - Silfverdal, Sven Arne

AU - Vyse, Andrew

AU - Borrow, Raymond

PY - 2016/5/3

Y1 - 2016/5/3

N2 - Adolescents have the highest rates of meningococcal carriage and transmission. Interrupting the adolescent habitat in order to reduce carriage and transmission within adolescents and to other age groups could help to control meningococcal disease at a population level. Compared to immunization strategies restricted to young children, a strategy focused on adolescents may have more profound and long-lasting indirect impacts, and may be more cost effective. Despite challenges in reaching this age-group, experience with other vaccines show that high vaccine coverage of adolescents is attainable.

AB - Adolescents have the highest rates of meningococcal carriage and transmission. Interrupting the adolescent habitat in order to reduce carriage and transmission within adolescents and to other age groups could help to control meningococcal disease at a population level. Compared to immunization strategies restricted to young children, a strategy focused on adolescents may have more profound and long-lasting indirect impacts, and may be more cost effective. Despite challenges in reaching this age-group, experience with other vaccines show that high vaccine coverage of adolescents is attainable.

KW - Neisseria meningitides

KW - adolescent

KW - carriage

KW - cost-effectiveness

KW - epidemiology

KW - herd protection

KW - transmission

KW - vaccine

UR - http://www.scopus.com/inward/record.url?scp=84961206831&partnerID=8YFLogxK

U2 - 10.1586/14760584.2016.1130628

DO - 10.1586/14760584.2016.1130628

M3 - Review article

C2 - 26651380

AN - SCOPUS:84961206831

SN - 1476-0584

VL - 15

SP - 641

EP - 658

JO - Expert Review of Vaccines

JF - Expert Review of Vaccines

IS - 5

ER -

Routinely vaccinating adolescents against meningococcus: Targeting transmission & disease

Abstract

Bibliographical note

Keywords

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this