Rotavirus genotyping: Keeping up with an evolving population of human rotaviruses

Miren Iturriza-Go'Mara; Gagandeep Kang; James Gray

doi:10.1016/j.jcv.2004.04.009

Rotavirus genotyping: Keeping up with an evolving population of human rotaviruses

Miren Iturriza-Go'Mara^*, Gagandeep Kang, James Gray

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

385 Citations (Scopus)

Abstract

The use of molecular methods for rotavirus characterisation provides not only increased sensitivity for typing, but also allows accurate and more complete characterisation of strains, and the identification of putative reassortant strains. However, due to the constant accumulation of point mutations through genetic drift, and to the emergence of novel genotypes, possibly zoonotic transmission and subsequent reassortment, the reagents and methods used require close monitoring and updating. Methods and oligonucleotide primers are described to overcome failures to type G9, G10 and P[11] rotavirus strains, and cross-reactivity identified between G10 and G3 rotaviruses.

Original language	English
Pages (from-to)	259-265
Number of pages	7
Journal	Journal of Clinical Virology
Volume	31
Issue number	4
DOIs	https://doi.org/10.1016/j.jcv.2004.04.009
Publication status	Published - Dec 2004

Bibliographical note

Funding Information:
Support for this work was obtained through an MRC Research Training Fellowship awarded to Miren Iturriza-Gómara and a Wellcome Trust Trilateral Infectious Disease Inititative Grant (No. 063144).

Keywords

Oligonucleotide primers
Rotavirus genotyping
Rotavirus strains

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.jcv.2004.04.009

Cite this

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title = "Rotavirus genotyping: Keeping up with an evolving population of human rotaviruses",

abstract = "The use of molecular methods for rotavirus characterisation provides not only increased sensitivity for typing, but also allows accurate and more complete characterisation of strains, and the identification of putative reassortant strains. However, due to the constant accumulation of point mutations through genetic drift, and to the emergence of novel genotypes, possibly zoonotic transmission and subsequent reassortment, the reagents and methods used require close monitoring and updating. Methods and oligonucleotide primers are described to overcome failures to type G9, G10 and P[11] rotavirus strains, and cross-reactivity identified between G10 and G3 rotaviruses.",

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AU - Kang, Gagandeep

AU - Gray, James

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AB - The use of molecular methods for rotavirus characterisation provides not only increased sensitivity for typing, but also allows accurate and more complete characterisation of strains, and the identification of putative reassortant strains. However, due to the constant accumulation of point mutations through genetic drift, and to the emergence of novel genotypes, possibly zoonotic transmission and subsequent reassortment, the reagents and methods used require close monitoring and updating. Methods and oligonucleotide primers are described to overcome failures to type G9, G10 and P[11] rotavirus strains, and cross-reactivity identified between G10 and G3 rotaviruses.

KW - Oligonucleotide primers

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KW - Rotavirus strains

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Rotavirus genotyping: Keeping up with an evolving population of human rotaviruses

Abstract

Bibliographical note

Keywords

UN SDGs

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