Rotavirus burden among children in the newly independent states of the former union of soviet socialist republics: Literature review and first-year results from the rotavirus Surveillance network

Radmila Mirzayeva*, Margaret M. Cortese, Liudmila Mosina, Robin Biellik, Andrei Lobanov, Lyudmila Chernyshova, Marina Lashkarashvili, Soibnazar Turkov, Miren Iturriza-Go'Mara, James Gray, Umesh D. Parashar, Duncan Steele, Nedret Emiroglu

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

20 Citations (Scopus)

Abstract

Background. Data on rotavirus burden among children in the 15 newly independent states of the former Union of Soviet Socialist Republics, particularly contemporary data from poorer countries, are not widely available. These data are desired by policy makers to assess the value of rotavirus vaccination, especially since the GAVI Alliance approved financial support for the regions eligible countries. The Rotavirus Surveillance Network was established to provide these data. Methods. We reviewed the regions literature on rotavirus burden.We established an active surveillance network for rotavirus and analyzed data from 2007 from 4 sentinel hospitals in 3 countries (Georgia, Tajikistan, and Ukraine) that were collected using standardized enrollment and stool sample testing methods. Results. Specimens for rotavirus testing were collected before 1997 in most studies, and the majority of studies were from 1 country, the Russian Federation. Overall, the studies indicated that ∼33% of hospitalizations for gastroenteritis among children were attributable to rotavirus. The Rotavirus Surveillance Network documented that 1425 (42%) of 3374 hospitalizations for acute gastroenteritis among children aged <5 years were attributable to rotavirus (site median, 40%). Seasonal peaks (autumn through spring) were observed. Genotype data on 323 samples showed that G1P[8] was the most common type (32%), followed by G9P[8] (20%), G2P[4] (18%), and G4P[8] (18%). Infections due to G10 and G12 and mixed infections were also detected. Conclusions. The burden of rotavirus disease in the newly independent states is substantial. Vaccines should be considered for disease prevention.

Original languageEnglish
Pages (from-to)S203-S214
JournalJournal of Infectious Diseases
Volume200
Issue numberSUPPL. 1
DOIs
Publication statusPublished - Nov 2009

Bibliographical note

Funding Information:
Supplement sponsorship: This article was published as part of a supplement entitled “Global Rotavirus Surveillance: Preparing for the Introduction of Rotavirus Vaccines,” which was prepared as a project of the Rotavirus Vaccine Program, a partnership between PATH, the World Health Organization, and the US Centers for Disease Control and Prevention, and was funded in full or in part by the GAVI Alliance.

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