Robust antibody responses in 70-80-year-olds 3 weeks after the first or second doses of Pfizer/BioNTech COVID-19 vaccine, United Kingdom, January to February 2021

Sathyavani Subbarao; Lenesha A. Warrener; Katja Hoschler; Keith R. Perry; Justin Shute; Heather Whitaker; Michelle O'Brien; Frances Baawuah; Paul Moss; Helen Parry; Shamez Ladhani; Mary Ramsay; Kevin Brown; Gayatri Amirthalingam

doi:10.2807/1560-7917.ES.2021.26.12.2100329

Robust antibody responses in 70-80-year-olds 3 weeks after the first or second doses of Pfizer/BioNTech COVID-19 vaccine, United Kingdom, January to February 2021

Sathyavani Subbarao, Lenesha A. Warrener, Katja Hoschler, Keith R. Perry, Justin Shute, Heather Whitaker, Michelle O'Brien, Frances Baawuah, Paul Moss, Helen Parry, Shamez Ladhani, Mary Ramsay, Kevin Brown, Gayatri Amirthalingam

Research output: Contribution to journal › Article › peer-review

28 Citations (Scopus)

Abstract

Sera were collected from 185 adults aged≥70 years in London to evaluate the immune response to COVID-19 vaccines. A single dose of Pfizer/BioNtech vaccine resulted in>94% seropositivity after 3 weeks in naïve individuals using the Roche Spike antibody assay, while two doses produced very high spike antibody levels, significantly higher than convalescent sera from mild-to-moderate PCR-confirmed adult cases. Our findings support the United Kingdom's approach of prioritising the first dose and delaying the second dose of COVID-19 vaccine.

Original language	English
Pages (from-to)	1-6
Number of pages	6
Journal	Eurosurveillance
Volume	26
Issue number	12
DOIs	https://doi.org/10.2807/1560-7917.ES.2021.26.12.2100329
Publication status	Published - 25 Mar 2021

Bibliographical note

Funding Information:
We would like to thank Dorothy Blundell, Dr Caroline Sayer and the team at Haverstock Healthcare GP Federation, Nick Andrews, Ezra Lindley, Cathy Rowe, Tim Brooks, Ashley Otter and the whole CONSESUS team at PHE. We also wish to thank staff within the Virus Reference Department at Colindale who assisted with the laboratory testing: Jake Hall, James Bull, Hamish Wilson, Chris Hudson, Thivya Kankeyan, Sammy Ho, Christine Carr, Sophie Stephens Vasiliki Zianta, Stuti Vaghadia and Shabnam Jamarani.

Publisher Copyright:
© 2021 European Centre for Disease Prevention and Control (ECDC). All rights reserved.

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10.2807/1560-7917.ES.2021.26.12.2100329

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Subbarao, S., Warrener, L. A., Hoschler, K., Perry, K. R., Shute, J., Whitaker, H., O'Brien, M., Baawuah, F., Moss, P., Parry, H., Ladhani, S., Ramsay, M., Brown, K., & Amirthalingam, G. (2021). Robust antibody responses in 70-80-year-olds 3 weeks after the first or second doses of Pfizer/BioNTech COVID-19 vaccine, United Kingdom, January to February 2021. Eurosurveillance, 26(12), 1-6. https://doi.org/10.2807/1560-7917.ES.2021.26.12.2100329

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title = "Robust antibody responses in 70-80-year-olds 3 weeks after the first or second doses of Pfizer/BioNTech COVID-19 vaccine, United Kingdom, January to February 2021",

abstract = "Sera were collected from 185 adults aged≥70 years in London to evaluate the immune response to COVID-19 vaccines. A single dose of Pfizer/BioNtech vaccine resulted in>94% seropositivity after 3 weeks in na{\"i}ve individuals using the Roche Spike antibody assay, while two doses produced very high spike antibody levels, significantly higher than convalescent sera from mild-to-moderate PCR-confirmed adult cases. Our findings support the United Kingdom's approach of prioritising the first dose and delaying the second dose of COVID-19 vaccine.",

author = "Sathyavani Subbarao and Warrener, {Lenesha A.} and Katja Hoschler and Perry, {Keith R.} and Justin Shute and Heather Whitaker and Michelle O'Brien and Frances Baawuah and Paul Moss and Helen Parry and Shamez Ladhani and Mary Ramsay and Kevin Brown and Gayatri Amirthalingam",

note = "Funding Information: We would like to thank Dorothy Blundell, Dr Caroline Sayer and the team at Haverstock Healthcare GP Federation, Nick Andrews, Ezra Lindley, Cathy Rowe, Tim Brooks, Ashley Otter and the whole CONSESUS team at PHE. We also wish to thank staff within the Virus Reference Department at Colindale who assisted with the laboratory testing: Jake Hall, James Bull, Hamish Wilson, Chris Hudson, Thivya Kankeyan, Sammy Ho, Christine Carr, Sophie Stephens Vasiliki Zianta, Stuti Vaghadia and Shabnam Jamarani. Publisher Copyright: {\textcopyright} 2021 European Centre for Disease Prevention and Control (ECDC). All rights reserved.",

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doi = "10.2807/1560-7917.ES.2021.26.12.2100329",

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Subbarao, S, Warrener, LA , Hoschler, K , Perry, KR, Shute, J, Whitaker, H, O'Brien, M, Baawuah, F, Moss, P, Parry, H, Ladhani, S , Ramsay, M , Brown, K & Amirthalingam, G 2021, 'Robust antibody responses in 70-80-year-olds 3 weeks after the first or second doses of Pfizer/BioNTech COVID-19 vaccine, United Kingdom, January to February 2021', Eurosurveillance, vol. 26, no. 12, pp. 1-6. https://doi.org/10.2807/1560-7917.ES.2021.26.12.2100329

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AU - Subbarao, Sathyavani

AU - Warrener, Lenesha A.

AU - Hoschler, Katja

AU - Perry, Keith R.

AU - Shute, Justin

AU - Whitaker, Heather

AU - O'Brien, Michelle

AU - Baawuah, Frances

AU - Moss, Paul

AU - Parry, Helen

AU - Ladhani, Shamez

AU - Ramsay, Mary

AU - Brown, Kevin

AU - Amirthalingam, Gayatri

N1 - Funding Information: We would like to thank Dorothy Blundell, Dr Caroline Sayer and the team at Haverstock Healthcare GP Federation, Nick Andrews, Ezra Lindley, Cathy Rowe, Tim Brooks, Ashley Otter and the whole CONSESUS team at PHE. We also wish to thank staff within the Virus Reference Department at Colindale who assisted with the laboratory testing: Jake Hall, James Bull, Hamish Wilson, Chris Hudson, Thivya Kankeyan, Sammy Ho, Christine Carr, Sophie Stephens Vasiliki Zianta, Stuti Vaghadia and Shabnam Jamarani. Publisher Copyright: © 2021 European Centre for Disease Prevention and Control (ECDC). All rights reserved.

PY - 2021/3/25

Y1 - 2021/3/25

N2 - Sera were collected from 185 adults aged≥70 years in London to evaluate the immune response to COVID-19 vaccines. A single dose of Pfizer/BioNtech vaccine resulted in>94% seropositivity after 3 weeks in naïve individuals using the Roche Spike antibody assay, while two doses produced very high spike antibody levels, significantly higher than convalescent sera from mild-to-moderate PCR-confirmed adult cases. Our findings support the United Kingdom's approach of prioritising the first dose and delaying the second dose of COVID-19 vaccine.

AB - Sera were collected from 185 adults aged≥70 years in London to evaluate the immune response to COVID-19 vaccines. A single dose of Pfizer/BioNtech vaccine resulted in>94% seropositivity after 3 weeks in naïve individuals using the Roche Spike antibody assay, while two doses produced very high spike antibody levels, significantly higher than convalescent sera from mild-to-moderate PCR-confirmed adult cases. Our findings support the United Kingdom's approach of prioritising the first dose and delaying the second dose of COVID-19 vaccine.

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ER -

Robust antibody responses in 70-80-year-olds 3 weeks after the first or second doses of Pfizer/BioNTech COVID-19 vaccine, United Kingdom, January to February 2021

Abstract

Bibliographical note

UN SDGs

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